Am  &P87.arm'}  Reactions  of  Kairine,  Antipyrine  and  Antifebrin.  493 
REACTIONS  OF  KAIRINE,  ANTIPYRINE  AND  ANTI- 
FEBRIN. 
Translated  from  L'Orosi,  1887,  pp.  114  and  274,  by  Jos.  W.  England,  Ph.  G. 
Kohn,  in  Jour.  oV Alsace-Lorr.,  gives  the  following  :  Kairine,  with 
a  drop  of  ferric  chloride  in  a  weak  aqueous  solution,  instantly,  as- 
sumes a  violet  color  that  rapidly  passes  to  brown.  An  excess  of  ferric 
chloride  to  a  strong  solution  of  kairine  produces  an  almost  black  pre- 
cipitate. Bichromate  of  potassium,  in  neutral  solution,  gives  an  in- 
tense coloration  and  separates  a  violet  pigment,  on  standing,  which, 
dissolved  in  alcohol,  forms  a  black  solution. 
Antipyrine  in  weak  solution,  forms  a  rose  color  with  ferric  chloride 
that  is  visible  in  a  1  to  100,000  solution.  With  nitrous  acid  added  to 
a  dilute  solution,  a  blue-green  color  is  produced,  while  in  the  con- 
centrated solution,  green  crystals  are  deposited. 
Antifebrin  with  the  reagents  previously  mentioned  undergoes  no 
change,  but  boiled  with  potassium  hydrate,  evidence  of  the  existence 
of  aniline  is  obtained  and,  after  distillation,  potassium  acetate  may  be 
found  in  the  retort.    (See  also  page  491.) 
In  the  Apoth.  Zeitung  the  following  test  is  given  for  antifebrin  : 
Boil  a  few  centigrams  of  antifebrin,  with  one  cc.  of  officinal  so- 
lution of  potassium  hydrate  and  hold  suspended  in  the  tube  a  glass 
rod,  which  has  been  dipped  in  a  solution  of  chlorinated  lime ;  the 
drop  of  solution  suspended  on  the  end  of  the  rod  will  acquire  an  am- 
ber color,  which,  on  continuing  the  ebullition,  passes  little  by  little  to 
violet.  This  violet  coloration  results  from  aniline,  which  is  produced 
from  the  antifebrin  by  the  boiling  caustic  potassa.  It  may  be  well  to 
further  note  that  if  the  test  is  made  directly  with  aniline,  the 
violet  coloration  of  the  drop  appears  at  once,  without  the  primary 
change  to  amber  color,  as  in  the  case  of  antifebrin. 
A  formula  for  ergot,  hypodermatically. — Hildebrandt  recom- 
mends the  following : 
Aqueous  extract  of  ergot  3  parts. 
Glycerin 
Distilled  water,  each   7  parts. 
From  five  to  twenty  drops  may  be  injected  beneath  the  integument  of 
the  thigh  or  abdomen  to  check  uterine  hemorrhage. — Journal  de  Medecine  ; 
Med.  News,  Aug.  20. 
