AmN?v.?iS7arm"}    Pharmaceutical  Notes  on  New  Compounds.  565 
The  remedy  is  thus  rendered  very  pleasant  to  take,  and  the  patients 
express  no  aversion  to  it. 
A  good  preparation  should  be  of  pure  white  color,  and  form  mod- 
erately large  crystals,  which  are  but  very  sparingly  soluble  in  cold 
water,  rather  more  readily  in  hot,  and  easily  in  alcohol;  antifebrin 
melts  at  233'6°,  and  boils  at  563°. 
Antipyrin,  oxydimethylchinizine,  C10H9CH3.N2O. — Antipyrin  may 
fairly  be  considered  the  most  popular  of  modern  antipyretics.  The 
dose  varies  from  15  to  30  grains  twice,  three  or  more  times  a  day. 
For  children  3  to  12  grains  will  be  found,  to  be  sufficient.  It  is  of 
great  value  in  all  febrile  diseases,  reducing  temperature  very  promptly. 
Of  late  it  has  also  been  applied  in  subcutaneous  injection  as  a  local 
anaesthetic.  In  some  cases  a  bright  pink  rash,  like  nettle  rash,  will 
suddenly  appear  during  treatment ;  this  is  considered  to  be  of  no  im- 
portance, as  it  causes  no  inconvenience  and  soon  disappears. 
Antipyrin  is  readily  soluble  in  water  and  alcohol ;  it  possesses  but 
little  flavor,  and  that  not  unpleasant ;  and  is,  therefore,  adapted  for 
administration  in  solution.  It  thus  possesses  great  advantages  over 
quinine,  especially  in  treating  children,  who  take  it  very  readily  if 
mixed  with  a  little  syrup,  thus  : — 
Antipyrin   80  gr. 
Simple  syrup    3j. 
Water,  add  to   ,   %iv. 
Two  teaspoonfuls  for  a  dose. 
This  mixture  is  almost  free  from  bitterness,  and  children  do  not  at 
all  object  to  it. 
It  crystallizes  in  colorless  laminae,  which  melt  at  a  temperature  be- 
tween 230°  and  235-4°  F. 
Antithermin,  phenylhydrazinlevulinic  acid, 
CH3C(C6H5N-NH)CH2-CH2COOH.— 
has  been  recommended  as  a  febrifuge,  but  although  it  is  now  obtain- 
able in  the  market,  details  are  still  wanting  as  to  dose  and  effect.  It 
forms  large  colorless  crystals  of  a  slightly  bitter  taste,  which  cause  an 
unpleasant  grating  when  ground  between  the  teeth.  It  is  insoluble  in 
water,  and  but  sparingly  soluble  in  alcohol.  The  most  suitable  form 
for  administering  antithermin  is  the  pilular. 
Aseptol,  acidum  sozolicum,  orthophenolsulphonic  acid, 
C6H4OHS02OH. 
