568        Pharmaceutical  Notes  on  New  Compounds.  { 
^m.  Jour.  Pharm* 
Nov.,  1887. 
Naphtol  =fi  naphtol,  isonaphtol,  C10H7OH. — As  a  substitute  for  tar 
preparations,  naphtol  has  been  applied  to  the  skin  with  very  good  re- 
sults, especially  in  psoriasis  and  other  chronic  affections.  A  two  to  five 
per  cent,  solution  in  alcohol  is  the  usual  form  of  application,  but  it  can 
also  be  made  up  into  ointment  containing  three  to  twenty-five  percent. 
Internal  administration  of  this  compound  was  attended  with  toxic 
effects,  and  has,  therefore,  been  discontinued. 
It  crystallizes  in  resplendent  scales,  has  an  aromatic  odor,  is  slightly 
soluble  in  hot  water,  readily  so  in  alcohol  and  fatty  oil.  A  very 
good  ointment  may  be  made  by  adding  one  part  of  naphtol  to  ten  of 
melted  lard  and  well  stirring.  The  substance  dissolves  without  much 
difficulty  and  forms  a  white,  smooth  product. 
Naphtol  melts  at  253°,  and  boils  at  546'8°. 
It  should  not  be  confounded  with  naphtalin. 
Salol,  phenylether  of  salicylic  acid,  C6H4OH.COO.C6H5.  This 
remedy  appears  to  give  the  greatest  promise  of  future  importance,  for 
in  the  short  time  that  it  has  been  known,  it  has  done  very  good  ser- 
vice as  a  febrifuge  and  an  anti-rheumatic,  being  administered  in  doses 
of  fifteen  to  thirty  grains  two  or  three  times  a  day,  as  also  as  a  gargle 
5ij.  thus — : 
Salol  
Spirit,  vin  ^  iv. 
A  teaspoonful  to  a  glass  of  warm  water  for  stomatitis  and  ulcera- 
tions of  the  mouth  and  pharynx. 
A  salol  mouthwash  is  also  very  much  recommended,  and  may  be 
prepared  as  follows : — 
Take  of  salol  gr.  40,  dissolve  in  5iv.  of  a  suitable  spirituous  dentifrice 
liquid.  Half  a  teaspoonful  to  be  used  in  a  glass  of  water,  with  which 
it  forms  a  milky  emulsion. 
For  chronic  forms  of  diphtheria,  it  is  reported  to  have  more  power- 
ful effect  than  solutions  of  chlorate  of  potassium  or  salicylic  acid.  It 
is  also  applied,  worked  up  with  butter  of  cacao  into  pencils,  as  an 
antiseptic.  These  are  prepared  in  a  similar  manner  to  those  of  betol 
before  mentioned. 
Salol  is  a  white  crystalline  powder  of  a  mild  aromatic  odor ;  it  is 
insoluble  in  water,  but  soluble  in  alcohol.  The  melting  point  is 
108°  F. 
Thallin  C9H10N(OCH3). — Thallin  is  employed  either  as  sulphate  or 
tartrate.    It  is  rapidly  obtaining  a  recognized  position  in  the  materia 
