ON HYDRATED PEROXIDE OF IRON, ETC 
241 
death was the termination.* M. Bouley, Jun., of Alfort, made 
an elaborate series of experiments on horses, and which were 
published in 1835. He ascertained, in the first place, that 
the peroxide was totally inefficacious in poisoning by arseni- 
ate of potash, (Fowler's solution,) and for a manifest "reason— 
the iron cannotovercome the affinityexisting between its con- 
stituents. But when he gave white arsenic in doses of two 
ounces and upwards, and followed it by sixty-four ounces of 
the hydrated oxide, the animals survived. In several in- 
stances, the horses thus treated were killed at the end of nine 
days, and the stomach and intestines bore the marks of the 
action of the poison, but evidently in a mitigated degree, 
and sufficient to show that it had been promptly counteracted. 
In one case, the antidote was delayed twenty-five hours, and 
the consequence was, the death of the animal twenty-four 
hours thereafter, and the stomach, intestines and heart bore 
marks of the violence of the poison.t 
MM. Miguel and Soubeiran of Paris were probably the 
next experimenters. They found that if a large dose of 
arsenic was given to dogs, and they w 7 ere allowed to vomit, 
it produced no effect, and it was therefore necessary to tie the 
oesophagus. But this in itself is a fatal operation, and the 
time that the animal could survive required to be ascertained. 
A dog whose oesophagus was tied, died in seventy-eight 
hours, but if nine or ten grains of arsenic were given, and the 
oesophagus then tied, death followed in two or two and a half 
hours. In their experiments they used the recently prepared 
peroxide of hydrated iron mixed with water, in the propor- 
tion of twelve parts, to one of white arsenic. 
In several instances of dogs thus treated, they survived 
from seventy-eight hours to six days. But if the exhibition 
of the antidote was delayed, the animals perished, and the 
♦American Journal of Medical Sciences, vol. xvi. p. 239. 
f Annales C'Hygiene, vol. xii. p. 134; American Journal, August,183&, 
p. 518. 
VOL. VII.— NO. tiU 
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