AmMJarch,i907.rm'}     Approved  Proprietary  Preparations.  115 
as  a  surgical  dressing  powder.  Prepared  by  Parke,  Davis  &  Co., 
Detroit,  Mich. 
BROMETONE. 
Brometone,  1,1,1-tribrom  -  2  -  methyl  -  propan  -  2-  ol,  CBr3-C(OrT 
(CH3)CH3  =  C4H-OBr3,  produced  by  the  reaction  of  acetone  on 
bromoform. 
Actions  and  Uses. — Brometone  is  claimed  to  have  the  sedative 
action  of  the  bromides  without  the  disadvantage  of  producing 
bromism.  In  doses  of  0  3  gramme  (5  grains)  four  or  five  times  a 
day,  in  adults,  it  is  claimed  to  cause  no  unpleasant  results  and  to  pro- 
duce no  disturbance  of  the  digestive  organs,  and  to  have  no  appre- 
ciable effect  on  the  secretions.  Its  action  is  prompt  and  its  effect  is 
manifest  for  several  hours.  In  doses  exceeding  I '6  grammes  (25 
grains)  daily  it  may  produce  dizziness,  vertigo,  anorexia,  and  mental 
hebetude,  all  of  which  symptoms  disappear  on  discontinuance  of  its 
use.  Therapeutically  it  has  been  recommended  in  mild  conditions 
of  excitation  and  insomnia,  in  so-called  narcotic  abstinence,  in  hys- 
teria, and  in  nervous  affections  generally.  It  relieves  some  forms  of 
cough  and  is  said  to  produce  amelioration  in  about  60  per  cent,  of 
cases  of  epilepsy.  It  has  been  used  to  relieve  dizziness  due  to  laby- 
rinthine disturbances.  Dosage. — T,he  dose  is  0-3  gramme  (5  grains), 
to  be  repeated  two  or  three  times  during  twenty-four  hours.  Manu- 
factured by  Parke,  Davis  &  Co.,  Detroit,  Mich. 
BROMIPIN. 
A  bromine  addition  product  of  sesame  oil,  containing  10  per  cent, 
of  bromine  in  organic  combination. 
Actions  and  Uses. — Bromipin  acts  like  the  bromides,  but  as  it 
yields  its  bromine  more  slowly  it  is  thought  to  have  less  tendency 
to  produce  brominism.  The  combination  is  not  broken  up  in  the 
stomach,  but  a  portion  of  the  bromine  is  split  off  as  soon  as  the  oil 
enters  the  intestine.  The  oil  with  the  remaining  bromine  is  easily 
absorbed,  and,  similarly  to  other  fats,  is  largely  deposited  in  the 
tissues,  where  it  is  slowly  split  up.  It  is  said  to  be  more  lasting  in 
its  action  than  the  bromides.  Dosage. — 4  c.c.  (1  fluidrachm),  in- 
creased in  cases  of  epilepsy  to  from  8  to  32  c.c.  (2  to  8  fluidrachms) ; 
in  emulsion  with  peppermint  water  and  syrup,  or  pure,  flavored  with 
oil  of  peppermint.  Manufactured  by  E.  Merck,  Darmstadt.  (Merck 
&  Co.,  New  York.) 
