Am.  Jour.  PtiKim. 
March.  1907. 
Approved  Proprietary  Preparations. 
117 
which  characterizes  the  ordinary  extract.  It  is  recommended  for 
the  treatment  of  chronic  constipation,  for  which  cascara  sagrada  is 
one  of  the  best  medicinal  agents.    Dosage. — As  a  laxative,  0-6  to 
1  c.c.  (10  to  1 5  minims)  three  times  a  day;  as  a  purgative,  1*3  to 
2  c.c.  (20  to  30  minims)  morning  and  evening.  Four  cubic  centi- 
meters (1  fluidrachm)  may  be  given  in  obstinate  cases.  Prepared  by 
Parke,  Davis  &  Co.,  Detroit,  Mich. 
CASCARA  TONIC  LAXATIVE  GLOBULES. 
Each  globule  is  said  to  contain  0  2  gramme  (3  grains)  of  the  bitter 
glucosides  of  Rhamnus  Purshiana  suspended  in  a  bland  fixed  oil,  to 
which  aromatics  have  been  added. 
Actions  and  Uses. — The  manufacturers  claim  that  it  combines  the 
laxative  action  of  cascara  with  tonic  properties  of  the  bitter  prin- 
ciple with  the  advantage  of  concealment  of  the  disagreeable  taste. 
Dosage. — One  or  two  globules  to  be  taken  before  retiring.  Pre- 
pared  by  Parke,  Davis  &  Co.,  Detroit,  Mich. 
CHINAPHENIN. 
Chinaphenin,  CO  (NH-C6H4OC2H5)  (C20H23N2O2)  =  Co0H33N3O4,  the 
quinine  carbonic  acid  ester  of  phenetidin. 
Actions  and  Uses. — Chinaphenin  combines  the  antiperiodic  prop- 
erties of  quinine  with  the  analgesic  power  of  phenacetin,  with  the 
advantage  of  tastelessness  and  asserted  freedom  from  symptoms  of 
cinchonism  produced  by  the  administration  of  the  two  remedies  in 
simple  mixture.  It  is  recommended  in  febrile  diseases,  especially  la 
grippe  ;  in  spasmodic  conditions,  such  as  whooping-cough  ;  in  cer- 
tain forms  of  malaria  and  in  neuralgia.  Dosage. — Adult :  0-3  to 
0-6  gramme  (5  to  10  grains)  ordinarily,  1*5  to  2  grammes  (22  to  30 
grains),  given  in  two  doses  as  an  antipyretic  in  neuralgia  and  malaria  ; 
in  whooping-cough  :  0*13  to  0-3  gramme  (2  to  5  grains),  according  to 
age.  Manufactured  by  Farbenfabriken,  vorm.  Friedr.  Bayer  &  Co., 
Elberfeld,  Germany  (Continental  Color  &  Chemical  Co.,  New  York). 
CHLORBUTANOL. 
Chlorbutanol,  1, 1,1  -  trichlor  -  2  -  methyl  -  propan  -  2  ol,  CC13-C 
(OH)  (CH3)  -CH3  —  C4H7OCh,  produced  by  the  reaction  of  acetone 
on  chloroform. 
Actions  and  Uses. — It  is  said  to  be  absorbed  unchanged,  but  to 
