Am.  Jour.  Ptiarm. 
March,  1907. 
Progress  in  Pharmacy. 
133 
of  orange  peel,  20*00 ;  alcohol,  iooo.  Mix  and  add  a  solution  of 
quinine  hydrochloride,  roo  in  distilled  water,  40^00  ;  and  syrup  of 
orange  peel,  20-00.  Mix,  and  then  add  the  following,  prepared  by 
slightly  warming  :  Ferric  pyrophosphate  with  ammonium  citrate, 
4  00  in  distilled  water,  40-00.  Mix,  and  add  syrup  of  orange  peel, 
40-00. 
Dose,  one  to  two  teaspoonfuls,  with  water,  two  or  three  times  a 
day. 
Novaspirin  is  the  name  applied  to  methyl  citric  acid  ester  of 
salicylic  acid.  It  occurs  as  a  white  powder  having  a  slightly  acid 
taste.  It  is  nearly  insoluble  in  water  but  is  readily  soluble  in  alcohol. 
Novaspirin  may  be  given  in  doses  of  1  gramme  three  times  a  day. 
(Phar.  Zeit.,  1907,  page  9.) 
Quinine  Phytinate. — Anhydro  oxymethylene  diphosphate  of  qui- 
nine occurs  as  a  yellow  powder,  very  soluble  in  water  but  almost 
insoluble  in  alcohol,  ether,  benzin  or  chloroform.  The  substance 
contains  57  per  cent,  of  quinine  and  has  an  intensely  bitter  taste. 
Scar  latin  Marpman  is  an  antitoxin  preparation  that,  given  inter- 
nally, is  being  used  as  a  prophylactic  for  scarlet  fever.  It  is  said  to 
be  produced  by  inoculating  animals  with  infectious  material  from 
scarlet-fever  patients  and  inoculating  other  animals  with  the  serum 
taken  from  the  first.  The  serum  from  the  blood  of  the  second 
animal  is  used  to  immunize  other  animals,  and  it  is  from  these 
immunized  animals  that  the  antitoxin  serum  is  prepared. 
Scarlatin  is  a  yellowish,  opalescent  liquid  having  a  slight  odor  and 
a  salty  taste.  The  substance  has  a  specific  gravity  of  from  1-012  to 
1-013,  is  neutral  in  reaction  and  gives  a  copious  precipitate  with 
reagents  for  albumin.    {Phar.  Centralh.,  1907,  page  69.) 
Solubility  of  Salicin. — D.  B.  Dott  {Phar.  Jour.,  1907,  page  79) 
finds  that  the  solubility  of  salicin,  as  given  in  the  British  Pharma- 
copoeia (1  in  28)  is  practically  correct,  while  that  of  the  U.  S.  P.  (1  in 
21  at  25 0  C.)  is  too  high. 
Using  pure  salicin,  that  melted  at  201°  C,  he  finds  that  it  has  a 
solubility  of  1  in  24  at  25 0  C,  or  very  nearly  that  called  for  by  the 
British  Pharmacopoeia  at  ordinary  temperatures. 
Substitutes  for  Cocaine. — Dr.  Hugo  Wintersteiner  ( Wiener  Mea. 
Wochensch.,  1906,  page  1339)  reports  a  comprehensive  comparative 
study  of  the  use  of  cocaine  and  its  various  substitutes  in  eye  work. 
Of  the  numerous  substances  that  have  been  proposed  from  time 
