American  Medical  Association. 
Am.  Jour.  Pharm  . 
April,  1907. 
salts  may  be  given  hypodermically  0-2  to  0-25  gramme  (3  to  4 
grains)  in  normal  saline  solution,  or  per  os  0.25  to  0.65  gramme  (4  to 
10  grains)  in  water  or  syrup.  The  calcium,  iron,  lithium,  magnesium 
and  manganese  salts  o-2  to  0-65  gramme  (3  to  10  grains)  doses, 
preferably  in  the  form  of  tablets;  the  quinine  salt  in  o-i  to  0-33 
gramme  (1^  to  5  grains),  and  the  strychnine  salt  in  o-oot  to  0-003 
gramme  (1  /60  to  I  /20  grain)  doses. 
HEDONAL. 
Hedonal,  CH3-CH2CH2-CH  (CH3)O  CO-NH2  ===  C6H1302  N,  a 
urethane  differing  from  ethyl  carbamate,  U.  S.  P.,  in  that  the  ethyl 
radicle  has  been  replaced  by  the  radicle  of  methylpropylcarbinol 
(pentan- 2-0I.)  CH3.CH2.CH2.CHOH.CH3. 
Actions  and  Uses. —  Hedonal  appears  to  have  a  greater  hypnotic 
effect  than  ethyl  carbamate.  It  is  said  to  be  followed  by  no  after, 
effects  and  is  oxidized  in  the  body  to  urea  and  carbon  dioxide.  It 
is  recommended  in  insomnia  due  to  mental  overwork  or  nervous 
excitement  occurring  in  the  course  of  neurasthenia  or  hysteria.  It 
is  claimed  to  be  particularly  useful  preliminary  to  anesthesia,  a  hyp- 
notic dose  being  given  and  anesthesia  effected  with  chloroform  after 
the  patient  has  been  asleep  for  an  hour.  Dosage. —  I  to  2  grammes 
(15  to  30  grains),  administered  dry,  followed  by  a  swallow  of  water, 
or  in  wafers  or  capsules.  Manufactured  by  Farbenfabriken,  vorm. 
Friedr.  Bayer  &  Co.,  Elberfeld,  Germany  (Continental  Color  & 
Chemical  Company,  New  York.) 
HEXAMETHYLENAMINE  METHYLENCITRATE.1 
This  substance,  C6H807  (CH2)  6N4  =  C12H20O7N4,  is  a  compound 
of  hexamethylenamine  with  anhydromethylencitric  acid. 
Actions  and  Uses. — It  is  a  urinary  antiseptic  and  germicide 
claimed  to  be  more  prompt  and  energetic  in  its  action  than  hexa- 
methylenamine, acting  equally  well  whether  the  urine  be  alkaline 
or  acid  in  reaction,  rapidly  clearing  it  up  and  allaying  pain.  Dosage. 
— 06  to  1  gramme  (10  to  15  grains). 
HOLOCAINE  HYDROCHLORIDE. 
Holocaine  hydrochloride.  CH3  C  (:N-C6H4OC2H5)  (-NH-C6H4- 
OC2H5  )  -HCI  =  C1SH22N202-HC1,  the  hydrochloride  of  a  basic  con- 
1  This  is  the  chemical  name  for  a  preparation  on  the  market  under  the 
names  of  helmitol  and  urotropin,  new. 
