278 
Progress  in  Phar7nacy. 
A_m.  Jour.  Priarm, 
June,  1907. 
Bromurol  is  the  mono  brom  isovalerianylurea  obtained  by  the 
condensation  of  urea  with  bromisovalerianylbromid.  It  occurs  as 
white,  nearly  tasteless  needles  soluble  in  hot  water,  alcohol  and 
ether,  but  only  slightly  soluble  in  cold  water. 
Bromurol  melts  at  about  145 0  C.  and  is  readily  sublimed.  It  has 
been  recommended  as  a  hypnotic  in  doses  of  from  0.3-  to  0-6.  [Phar. 
Cenfh,  1907,  page  143.) 
Mensulin  is  said  to  be  di  methyl  pyrazolon  hexahydro  cynol 
valerianate.  It  occurs  as  a  white,  somewhat  hygroscopic  powder, 
but  is  now  marketed  in  tablet  form  as  a  sedative  in  nervous  and 
menstrual  disorders.    [Phar.  Centli,  1907,  page  172.) 
Metramin  is  said  to  be  but  another  addition  to  the  already  numerous 
names  for  hexarriethylentetramin.    [Phar.  Cenfh,  1907,  page  340.) 
Monotol  is  an  ethyl  glycol  acid  ester  of  guaiacol,  and  at  about  31 0 
or  below  occurs  as  a  white  crystalline  mass  that  melts  readily  at  the 
normal  temperature  of  the  body  to  a  colorless  somewhat  aromatic 
oily  liquid.  It  is  said  to  possess  the  analgesic  properties  of  guaiacol 
and  is  preferably  used  by  inunction. 
Monotol  is  but  slightly  soluble  in  water,  but  is  readily  soluble  in 
fats  and  the  fatty  oils.    [Phar.  Cent'k,  1907,  page  172.) 
Mutton  Tallow  as  an  Excipient  for  Pills.— ^Keratin.coated  pills  not 
infrequently  pass  through  the  intestinal  tract  without  being  dissolved. 
Zaworski  recommends  that  in  place  of  any  coating  mutton  tallow 
be  used  as  an  excipient.  Pills  made  with  this  excipient  are  not 
affected  in  the  stomach  but  are  readily  disintegrated  in  the  small 
intestine.  Preparations  of  arsenic  and  of  mercury,  iodine,  benzoic, 
carbolic,  salicylic  and  tannic  acids,  creosote,  guaiacol  and  copaiba 
are  all  used  in  this  way.  The  melting  point  of  the  mutton  tallow 
should  be  about  45  0  C,  and  each  pill  should  not  contain  more  than 
0.10  of  tallow  and  an  equal  amount  of  medicament  or  other  diluent. 
[Phar.  Cenfh.,  1907,  page  292,  from  Therap.  Monatsh.) 
Pittylen  is  a  dry  amorphous  powder  having  a  yellowish  brown 
color  and  a  slight  tar-suggesting  odor.  It  is  soluble  in  alcohol, 
ether,  acetone,  chloroform,  turpentine  and  dilute  solutions  of  the 
alkalies.  It  is  said  to  be  a  condensation  product  of  wood  tar  with 
formaldehyde  and  is  therefore  a  variable  mixture  of  the  normal 
constituents  of  tar.    [Apothek.  Zeifg,  1907,  page  249.) 
Quinine  Tannate. — The  Academy  of  Medicine  of  Rome,  Italy, 
recently  passed  a  resolution  asking  the  government  to  have  quinine 
