306 
Alkaloidal  Assay. 
Am.  Jour.  Pharm. 
July,  1907. 
excess  of  that  solvent,  the  results  marked  44  Total  "  were  obtained 
by  means  of  a,  mixture  of  chloroform  and  ether. 
In  the  cases  of  fluid  extracts  of  gelsemium  and  veratrum  where 
the  menstruum  is  95  per  cent,  alcohol,  075  gramme  of  tartaric  acid 
was  added  directly  to  5  c.c.  of  the  fluid  extract ;  the  precipitate,  if 
any,  filtered  off  and  filter  washed  with  absolute  alcohol,  etc. 
The  following  table  gives  a  list  of  the  preparations  to  which  the 
process  has,  so  far,  been  applied,  and  also  the  results  compared  with 
those  obtained  when  the  principles  of  the  U  S. P.  processes  were 
followed : 
U.S. P.  Process.1  Tartaric  Acid  Process 
I 
II 
III 
IV 
V 
VI 
Quantity  Result 
Quantity 
First  Second 
Mean. 
taken. 
per  cent. 
taken. 
result,  result. 
Fluid  Extracts. — 
0*403  Total 
H  c.c. 
0-402 
0*400 
0-401 
Belladouna  root  . 
o-399 
0-403 
0-398 
0-4005 
Belladonna  leaf  .  . 
0  302 
0309 
0  301 
0-305 
<< 
J  0  504  Ether-sol.  ' ' 
|o*6o  Total 
o-62 
061 
0  615 
Conium  fruit  .  .  .  . 
f  0*292  Wt 
{0-296  AgNO-j 
0  3136  0-309 
0-311 
-  ¥" 
f  o*i8  Wt 
to- 1 1  AgN03 
o'o6 
o-o6 
o'o6 
5  " 
°'399 
0*391 
Lyons'  equiv.  (4  8)2 
0-355 
0-350 
0-352 
Lyons'  equiv.  (139)2 
0*076 
0-087 
0-087 
0-087 
Use  half  specified 
quantities  of  weak 
acid  to  dissolve  and 
wash  alcoholic  ex- 
Ipecacuanha .  .  . 
.  .  10  c.c. 
1-38  Total 
1-38 
i-38 
1-38  ■ 
tract.     Use  pow- 
dered NaHCOg 
instead  of  KOH 
solution  to  free 
_  alkaloids. 
0-396 
0*402 
0-396 
0  399 
0-251 
0-255 
0-252 
0*253 
Veratrum  Viride  . 
5  " 
o'35 
o*35 
f  Bredemann's  eq.  (424)8 
\  By  wt.  0*44  per  cent.  • 
Solid  Extracts. — 
Belladonna  rcot  . 
.  .  5gms. 
1 -64 
1  gms. 
171 
1-64 
i*68 
Belladonna  leaf 
1418 
144 
1-42 
1 '43 
•  •  1  " 
f3'8  Wt 
1  3'3  Ag-NOg 
3'4 
3-35 
3'37 
J  0*75  Wt 
(.0-51  AgNO.3 
0*431 
0-431 
0-431 
Hyoscyamus    .  .  . 
10  " 
0-308 
0-32 
0-30 
t'o*3i 
'  Use  powdered 
(  1 -6  Ether-sol. 
1-98 
i'95 
1*96  - 
NaHCOg  instead  ot 
J  2  0  Total 
KOH   solution  to 
.  free  alkaloids. 
•  •   5  " 
0-99 
1-02 
roo 
I'OI 
The  following  gives  the  process  in  detail  : — 
Add  gradually  10  c.c.  of  the  fluid  extract  to'85  c.c.  of  cold  absolute 
1  Modified  if  necessary. 
2  "Assay  of  Drugs,"  Lyons. 
3P.A.P.A.,  1906,  936.    Ex.  Apoth.  Ztg.,  xxi,  Nos.  5  and  6  (1906),  41  and  53, 
