Am'/i?iyr;m7arm'}    Lloyd  Reaction  as  Appliea  to  Heroin.  317 
The  composition  of  the  residues  was  not  determined.  Their 
origin  may  possibly  be  due  to  polymerization.  It  is  evident  that  a 
petroleum  ether  of  this  sort  is  not  adapted  for  use  in  making 
extractions. 
In  this  connection  it  may  not  be  out  of  place  to  state  that  some 
experiments  were  made  with  Kahlbaum's  "  Ethyl  ether  distilled 
over  sodium,"  obtained  from  newly  opened,  original  glass  bottles 
having  Kahlbaum's  seal  attached.  In  the  case  of  100  c.c.  taken 
from  one  bottle  and  evaporated  to  dryness  spontaneously  and  then 
at  100°  C,  a  solid  residue  of  0-0033  gramme  remained,  and  in  the 
case  of  100  c.c.  from  another  bottle  of  the  same  importation,  a  solid 
residue  of  0*0027  gramme  remained.  The  residue  was  insoluble  in 
95  per  cent,  alcohol,  slightly  soluble  in  absolute  alcohol,  soluble  in 
chloroform. 
THE  LLOYD  REACTION  AS  APPLIED  TO  HEROIN  AND 
VERATRIN* 
By  Daniel  W.  Fftteroi,f,  Ph.G.,  M.D.,  of  Philadelphia. 
[From  the  Robert  Hare  Laboratory  of  Chemistry,  Department  of  Medicine,  University  of 
Pennsylvania] 
The  name  Lloyd  reaction  was  suggested  by  Seward  W.  Williams1 
after  investigating  the  reaction  produced  by  a  mixture  of  the  alka- 
loids hydrastin  and  morphine,  when  treated  with  sulphuric  acid  and 
potassium  dichromate,  described  by  John  Uri  Lloyd,  in  his  popular 
novel,  "  Stringtown  on  the  Pike."  2  Lloyd  used  this  reaction  in  the 
expert  testimony  at  the  trial  of  (his  character)  Red  Head,  as  a  fallacy 
to  the  "  color  reaction  "  for  strychnine,  because  both  yield  a  blue- 
violet  in  the  play  of  colors  produced  with  sulphuric  acid  and  potas- 
sium dichromate.  This  reaction  has  been  investigated  by  Williams,1 
Wharton,3  Wangerin,4  Kebler,5  Mayer6  and  Fetterolf,7  all  of  whom 
agree  in  the  improbability  of  this  color  reaction  being  mistaken  for 
that  produced  by  strychnine.  Mayer  also  has  partially  studied  it 
with  various  alkaloids. 
CHEMICALS  EMPLOYED. 
The  chemicals  employed  in  the  experiments  detailed  in  this  paper 
were  as  follows :  Chemically  pure  sulphuric  acid  and  potassium,  di- 
*  Read  before  the  Philadelphia  Section  of  the  American  Chemical  Society, 
May  16,  1907. 
