Am*.Tuiyr,'i907arm' }    Lloyd  Reaction  as  Applied  to  Heroin.  319 
water-bath,  and  while  on  the  water-bath  the  reagents  were  added 
and  stirred  with  a  pointed  rod  glass  for  five  minutes. 
EXPERIMENTS. 
In  a  series  of  experiments  with  dry  mixtures  of  the  alkaloids 
containing  respectively,  1  mgm.  of  hydrastin  to  0-5,  i,  5,  9  and  10 
mgms.  of  heroin,  sulphuric  acid  alone  yielded  a  pink  or  reddish- 
brown  color  in  ten  to  twenty  seconds,  passing  through  various 
TABIvK  I. 
Ratio  Hydrastin 
to  Heroin. 
Quantity  of 
Alkaloids  in 
Milligrams. 
Sulphuric  acid  4  drops  (o'i  c.c.) 
brought  in  contact  with  the  dry 
mixture  of  the  alkaloids  and 
slowly  stirred,  with  a  pointed 
glass  rod,  for  five  minutes. 
A  minute  fragment  of  potassium 
dichromate  stirred  in  4  drops 
(o"i  c.c.)  of  sulphuric  acid  until 
the  fluid  was  distinctly  yellow  ; 
the  fluid  with  the  fragment 
brought  in  contact  with  the  dry 
mixture  of  the  alkaloids  and 
slowly  stirred,  with  a  pointed 
glass  rod,  for  five  minutes. 
Hydrastin. 
Heroin. 
1  to  10 
ro 
IO'O 
Reddish-brown  in  thirty  seconds, 
changing  to  pink  in  fifty  sec- 
onds, to  pale  blue-violet  in  one 
and  one  half  minutes,  passing 
through  various  shades  of  violet 
in  one  hour. 
Reddish-brown  with  red-brown 
streaks  following  the  fragment 
when  drawn  through  the  mix- 
ture in  five  seconds,  changing 
to  pink  in  ten  seconds,  to  pale 
blue-violet  in  two  minutes,  pass- 
ing through  various  shades  of 
violet  with  blue-violet  streaks 
following  the  fragment,  into 
pink-brown  in  five  minutes. 
1  to  9 
ro 
9-0 
Same  as  in  the  one  preceding. 
Same  as  in  the  one  preceding, 
except  the  blue-violet  color  was 
produced  in  thirty  seconds. 
1  to  5 
ro 
Same  as  in  the  one  immediately 
preceding,  except  the  blue-violet 
appeared  in  thirty  seconds  and 
changed  to  red-violet  in  three 
minutes. 
Same  as  in  the  one  immediately 
preceding,  except  the  violet  color 
was  permanent  for  several  hours. 
1  to  I 
ro 
I'd 
Pink  in  ten  seconds,  changing 
to  blue-violet  in  fifteen  to  twenty 
seconds,passing  through  various 
shades  ot  violet  to  red-violet  in 
five  minutes,  permanent  for  one 
and  one-half  hours,  then  slowly 
disappearing. 
Same  a9  in  the  one  immediately 
preceding,  except  the  final  color, 
which  was  dark  brown  to  black 
in  eight  minutes. 
1  to  % 
ro 
0-5 
Same  as  in  the  one  immediately 
preceding,  except  the  blue-violet 
color  appeared  in  one  minute. 
Same  as  in  the  one  immediately- 
preceding. 
shades  of  violet  in  three  to  five  minutes,  slowly  fading  away  in 
twenty  minutes  in  the  smaller  proportions,  and  in  the  larger  propor- 
tions in  an  hour  and  a  half. 
Mixtures  of  identical  quantitative  composition,  treated  with 
sulphuric  acid  and  potassium  dichromate,  yielded  a  red-brown  color, 
with    red-brown   streaks    following   the   fragment  of  potassium 
