320  Lloyd  Reaction  as  Applied  to  Heroin.  {Anjji^i^7arm' 
dichromate  as  drawn  through  the  mixture  in  five  seconds,  changing 
to  pink  in  ten  seconds,  to  blue-violet  in  thirty  seconds  to  two  min- 
utes, passing  through  various  shades  of  violet  with  blue-violet 
streaks  following  the  fragment  of  potassium  dichromate.  The  violet 
color  permanent  for  several  hours  in  some  instances  and  in  others 
changed  to  pink-brown  or  dark-brown  to  black  in  five  to  eight 
minutes. 
The  method  of  application  of  the  tests  with  the  results  obtained 
are  given  in  Table  I. 
table;  ii. 
drastin 
roin. 
Quantity  of 
Alkaloids  in 
Milligrams. 
Sulphuric  acid  4  drops  (o"i  c.c.) 
brought  in  contact  with  the  dry 
mixture  of  the  alkaloids  and 
slowly  stirred,  with  a  pointed 
A  minute  fragment  of  potassium 
dichromate  stirred  in  4  drops  (o*i 
r»  r*  1  of"  sii  1  T^H n tic*  opifl  until  tTip 
V-  ^ .  J    \JL    5  Uipil  U.1  1V_    aLl LI     U  U  L 1 1  1.11C 
fluid  was  distinctly  yellow;  the 
Ratio  Hy 
to  Hei 
Hydrastin. 
Heroin. 
glass  rod,  for  five  minutes. 
fluid  with  the  fragment  brought 
in  contcict  Tritli  the  dry  mixture 
of  the  alkaloids  and  slowly 
stirred,  with  a  pointed  glass  rod, 
for  five  minutes. 
10  to  10 
I0"0 
IO'O 
Reddish-brown  to  pale  pink  in 
ten  seconds,  changing  to  blue- 
violet  in  twenty  seconds,  passing 
through  various  shades  of  violet 
for  several  hours. 
Reddish-brown  with  red-brown 
streaks  following  the  fragment 
when  drawn  through  the  mixture 
in  five  seconds,  changing  to  pink 
in  ten  seconds,  to  blue-violet  in 
fifteen  to  twenty  seconds,  with 
dark  blue-violet  streak  following 
the  fragment,  passing  through 
various  shades  of  violet  for  sev- 
eral hours. 
9  to  i 
g-o 
I'd 
Same  as  in  the  one  preceding, 
except  the  blue-violet  color  was 
pale  and  occurred  after  the  lapse 
of  thirty  to  forty  seconds  and 
disappeared  in  two  hours. 
Same  as  in  the  one  preceding, 
except  the  blue-violet  color  was 
produced  in  thirtjT  seconds,  pass- 
ing through  various  shades  of 
violet  to  dark-brown  in  five  min- 
utes. 
5  to  i 
5*o 
I'O 
Same  as  in  the  one  immediately 
preceding. 
Same  as  in  the  one  immediately 
preceding. 
2  to  I 
2*0 
I'O 
Same  as  in  the  one  immediately 
preceding. 
Same  as  in  the  one  immediately 
preceding. 
I  to  I 
0*01 
O'OI 
*No  reaction  at  room  tempera- 
ture, but  between  8o°-9o°  C.  a 
momentary, very  pale  blue- violet 
color  was  produced. 
*No  reaction  at  room  tempera- 
ture, nor  between  8c°-90°  C, 
except  the  yellow  to  greenish 
color  of  the  fragment  and  acid. 
♦Only  two  drops  (0*05  c.c.)  sulphuric  acid  employed. 
Mixtures  of  the  same  quantitative  content  of  alkaloids,  at  a 
temperature  between  8o°  C.  and  900  C,  treated  with  sulphuric  acid 
alone  or  with  sulphuric  acid  and  potassium  dichromate,  produced 
the  blue-violet  color  immediately  or  in  five  seconds,  quickly  chang- 
ing to  blue-violet,  passing  through  various  shades  of  red-violet  to 
violet-red,  finally  to  black,  due  to  charring,  in  one  and  a  half  to 
fifteen  minutes. 
