Am'juiy?i?o7frm1    Lloyd  Reaction  as  Applied  to  Heroin.  321 
The  mixture  containing  the  proportion  of  1  mgm.  of  hydrastin 
to  5  mgms.  of  heroin  gave  the  most  marked  play  of  colors,  both  at 
room  temperature  and  between  8o°  C.  and  900  C. 
With  mixtures  of  hydrastin  and  morphine  the  best  results  were 
obtained  when  they  were  in  the  proportion  of  1  to  g9,  correspond- 
ing to  the  results  obtained  by  Lloyd. 
Another  series  of  mixtures  composed  respectively  of  1  mgm.  of 
heroin  to  2,  5,  9  and  10  mgms.  of  hydrastin,  treated  with  sulphuric 
acid  alone  or  with  sulphuric  acid  and  potassium  dichromate,  both  at 
room  temperature  and  between  8o°  C.  and  900  C,  yielded  results 
somewhat  similar  to  the  mixtures  previously  described.  The  results 
are  given  in  Table  II. 
The  results  obtained  from  a  mixture  composed  of  10  mgms.  of  each 
alkaloid  is  given  in  Table  II,  as  is  also  the  limit  of  the  reaction  for 
heroin. 
The  mixture  consisting  of  10  mgms.  of  each  alkaloid,  heated 
between  8o°  C.  and  900  C ,  and  treated  with  sulphuric  acid  alone, 
yielded  a  pale  pink  color  in  five  seconds,  becoming  blue-violet  in  ten 
seconds,  passing  through  various  shades  of  violet  into  black  with 
a  greenish  margin  in  half  an  hour,  the  whole  mass  assuming  a  dark 
green  color  on  cooling.  With  sulphuric  acid  and  potassium  dichro- 
mate it  gave  an  immediate  blue-violet  color,  changing  to  red-violet 
in  fifteen  seconds,  passing  through  various  shades  of  violet  to  black 
with  a  greenish  margin  in  five  minutes,  becoming  a  dark-green  color 
throughout  the  entire  mass  on  cooling.  A  final  green  color  is  pro- 
duced in  mixtures  composed  respectively  of  2  mgms.  and  5  mgms. 
of  hydrastin  to  1,  2,  4,  6,  9,  12  and  15  mgms.  of  morphin,  when 
treated  with  sulphuric  acid  alone,  at  room  temperature,  after  stand- 
ing from  a  half  to  two  hours.16  Mixtures  of  hydrastin  and  apomor- 
phin  also  yield  a  green  color  in  the  play  of  colors.11 
With  the  Lloyd  reaction  heroin  yields  results  somewhat  similar 
to  morphin  and  apomorphin.  The  only  difference  noted  was,  that 
the  beginning  yellow  and  brownish-yellow  color  in  the  mixtures  of 
morphin,  and  the  yellowish-brown  in  the  mixtures  of  apomorphin, 
was  substituted  by  a  pink  or  reddish-brown  color  with  heroin. 
Also,  the  green  color  produced  by  mixtures  of  morphin  and 
apomorphin  at  room  temperature  was  produced  in  mixtures  of 
heroin  only  when  a  large  quantity  of  each  alkaloid  was  present  and 
the  temperature  was  between  8o°  C.  and  900  C.    These  differences, 
