Am  j^'iSrf™*}    Lloyd  Reaction  as  Applied  to  Heroin.  323 
and  900  C.  a  dirty,  brownish-grey  color  was  produced,  which 
changed  to  green  (due  to  acid  and  dichromate)  in  three  minutes. 
Therefore,  the  red-brown  and  pink  colors  produced  by  mixtures  of 
hydrastin  and  heroin  are  due  to  heroin  alone,  as  hydrastin  produces 
no  brown  or  pink  when  treated  with  sulphuric  acid  alone. 
VERATRIN  MIXTURES. 
Mixtures  containing  respectively  I  mgm.  of  hydrastin  to  I,  3,  and 
5  mgms.  of  veratrin  treated  with  sulphuric  acid  yielded  an  imme- 
diate brilliant  yellow  color,  changing  to  brown-yellow  to  red-brown 
with  a  violet-blue  margin  in  three-quarters  of  a  minute,  becoming 
brilliant  cherry-red  in  five  minutes,  slowly  changing  to  red-violet 
after  several  hours,  the  latter  color  being  permanent  more  than 
twenty-four  hours.  Mixtures  of  identical  quantitative  composition 
treated  with  sulphuric  acid  and  potassium-  dichromate  produced  a 
brilliant  yellow  color  immediately,  changing  to  brownish-yellow,  to 
red-brown  with  a  blue-violet  margin  in  half  a  minute,  becoming  red- 
violet  in  three  minutes,  to  pink-brown  in  five  minutes,  which  per- 
sisted several  hours. 
With  mixtures  composed  respectively  of  o*i  mgm.  of  hydrastin 
to  01,  03,  0-5,  0-7  and  i-o  mgm.  of  veratrin,  when  treated  with 
sulphuric  acid,  and  with  sulphuric  acid  and  potassium  dichromate, 
results  similar  to  those  obtained  with  the  previously  described  mix- 
tures were  obtained. 
Mixtures  composed  respectively  of  o-oi  mgm.  of  hydrastin  to 
o-oi,  0-06  and  0-09  mgm.  of  veratrin,  treated  with  sulphuric  acid, 
yielded  a  yellow  color,  passing  through  various  shades  of  yellow  to 
pale  pink  in  five  minutes,  except  in  the  mixture  containing  o  01 
mgm.,  which  required  twenty  minutes  to  develop  a  pale-pink  tint. 
Mixtures  composed  of  the  same  quantities  of  the  alkaloids  as 
stated,  treated  with  sulphuric  acid  and  potassium  dichromate,  pro- 
duced a  pink-brown  with  yellow  color  disappearing  in  one-half 
minute  on  stirring. 
Mixtures  composed  respectively  of  o-OOi  mgm.  of  hydrastin  to 
O-OOI,  0006  and  0  009  mgm.  of  veratrin,  when  treated  with  sulphuric 
acid,  produced  a  very  pale  yellow  color  changing  to  a  very  pale  pink 
in  twenty  to  thirty  minutes.  Mixtures  of  the  same  quantitative 
content  of  alkaloids,  treated  with  sulphuric  acid  and  potassium 
dichromate,  yielded  a  pale  pink  color  disappearing  in  fifteen  seconds 
