Am.  Jour.  Pharm. 
July,  1907. 
}•    Lloyd  Reaction  as  Applied  to  Heroin. 
325 
OC2H5 
/ 
17 
NO  —  HC1  +  H20 
/ 
OH 
produced  a  more  decided  bright  blue  color  than  the  violet  obtained 
with  morphin,  apomorphin,  or  heroin.  Similar  mixtures  containing 
dionin  treated  with  sulphuric  acid  and  potassium  dichromate  yielded 
a  very  decided  blue  color. 
Dionin  alone  treated  with  sulphuric  acid  dissolved  with  efferves- 
cence to  a  colorless  solution  undergoing  no  change  in  fifteen  minutes. 
Between  8o°  and  900  C.  a  pale  pink  colored  solution  was  produced 
in  five  to  ten  minutes. 
Dionin  alone  treated  with  sulphuric  acid  and  potassium  dichromate 
yielded  no  color  other  than  the  yellow  of  the  acid  and  dichromate. 
Between  8o°  and  900  C.  it  produced  a  dirty  green  color  in  five 
minutes. 
No  violet  or  blue  color  was  produced  by  dionin  when  treated  with 
sulphuric  acid  alone  or  with  the  acid  and  dichromate. 
This  compound  and  other  alkaloids  are  under  further  investigation 
regarding  their  behavior  with  the  Lloyd  reaction. 
1  Williams  :  Druggists'1  Circular,  April,  1901,  page  73. 
2  Lloyd  :  "  Stringtown  on  the  Pike,"  1901,  page  406. 
3  Wharton  :  Druggists'  Circular,  March,  1901,  page  48. 
4  Wangerin  :  American  Druggist  and  Pharmaceutical  Record,  February, 
1903,  page  66  ;  Pharmaceutische  Zeitung  von  Berlin,  January,  1903. 
5  Kebler  :  American  Journal  of  Pharmacy,  July,  1903,  page  337. 
6  Mayer  :  American  Journal  of  Pharmacy,  July,  1901,  page  353. 
7  Fetterolf :  American  Medicine,  Vol.  IX,  Nos.  21,  22  and  23,  pages  868-871, 
905-906,  947-95°,  May  27,  June  3  and  10,  1905. 
8  Fetterolf :  American  Medicine,  Vol.  IX,  1905,  page  950. 
9  Fetterolf  :  American  Medicine,  Vol.  IX,'  1905,  page  906. 
10  Fetterolf :  American  Medicine,  Vol.  IX,  1905,  page  869,  table  I  and  II. 
11  Fetterolf :  American  Medicine,  Vol.  IX,  1905,  page  948,  table  XI  and  XII. 
12  Fetterolf :  American  Medicine,  Vol.  IX,  1905,  page  905,  table  IX. 
13  Fetterolf :  American  Medicine,  Vol.  IX,  1905,  page  948,  table  XIII. 
14  Wormley  :  "  Micro-chemistry  of  Poisons,"  second  edition,  page  664. 
BIBLIOGRAPHY. 
