Am.  Jour.  Pharrn.  \ 
September,  1907.  J 
Fluidgly cerate  of  Krameria. 
411 
one-fourth  or  less  was  present,  decomposition  invariably  took  place 
sooner  or  later. 
At  the  suggestion  of  Dr.  A.  Haines  Lippincott,  of  Camden,  I 
have  recently  prepared  a  liquid  preparation  of  krameria  with  gly- 
cerin as  a  solvent  and  of  the  same  drug  strength  as  the  official  fluid 
extract,  and  have  named  same  Fluidglycerate  of  Krameria. 
The  term  "Fluidglycerate"  is  used  here  as  a  distinct  title  for  a 
type  of  what  is  proposed  as  a  new  class  of  liquid  pharmaceutical 
preparations  made  with  glycerin  or  mixtures  of  glycerin  and  water 
as  solvents,  and  of  the  same  drug  strength  as  the  official  fluidex- 
tracts,  namely,  one  gramme  of  the  drug  to  each  cubic  centimeter  of 
the  product,  and  it  is  believed  that  a  number  of  such  stable  prepara- 
tions can  be  made. 
The  title  "  fluidglycerate  "  will  likewise  serve  to  distinguish  these 
preparations  of  a  definite  and  uniform  strength  from  the  products 
of  varying  proportions  now  official  in  the  United  States  Pharmaco- 
poeia as  "  Glycerites,"  and  in  the  British  Pharmacopoeia  as  "  Glycer- 
ins/' and  likewise  from  the  host  of  commercial  products  sold  as 
"  glyceroles." 
A  number  of  drugs  will  yield  their  active  medicinal  constituents 
to  glycerin  menstruums,  and  the  resulting  fluidglycerates,  being 
practically  free  from  resinous  matters,  will  be  miscible  with  water 
with  little  or  no  precipitation. 
The  following  is  the  formula  for  Fluidglycerate  of  Krameria: 
Krameria,  in  number  20  powder  1000  grammes. 
Glycerin  .  .  .  ,  500  cubic  centimeters. 
Water,  a  sufficient  quantity  to  make  1000  cubic  centimeters. 
Mix  the  glycerin  with  2000  cubic  centimeters  of  water,  and  having 
moistened  the  krameria  with  a  portion  of  this  menstruum,  pack  it  in 
a  percolator,  pour  on  enough  of  the  menstruum  to  saturate  the 
powder  and  leave  a  layer  of  liquid  above  it  and  allow  it  to  macerate 
for  twenty-four  hours.  Then  allow  the  percolation  to  proceed 
slowly,  pouring  on  first  the  remainder  of  the  menstruum  and  then 
water  until  the  drug  is  exhausted.  Reserve  the  first  600  c.c.  of 
percolate  and  evaporate  the  remainder  to  400  c.c.  When  coo1,  add 
the  reserve,  and  if  necessary  water,  to  make  the  product  measure 
1000  c.c. 
The  product  is  a  syrupy  liquid  of  a  deep  brownish-red  color  and 
a  strong  astringent  taste.    It  is  miscible  with  water,  making  an 
