Am.  Jour.  Pharm."! 
September,  1907.  J 
Progress  in  Pharmacy. 
425 
Hatcher  concludes  by  advising  cautious  clinicians  not  to  experi- 
ment with  isopral  except  in  carefully  selected  cases. 
Aspirophen.  (See  also  Am.  Jour.  Pharm.,  1906,  page  579). — 
Zernik  has  recently  demonstrated  that  this  substance  is  not  a  true 
chemical  combination,  as  claimed  by  the  manufacturers,  but  is  a 
simple  mixture  of  molecular  quantities  of  free  salicylic  acid  and 
mono  acetyl  phenocoll.    {Phar.  Post,  1907,  page  410.) 
Cinnamylcacodylic  Acid. — Crinon  states  that  this  substance  con- 
sists of  equal  parts  of  cacodylic  acid  and  cinnamic  acid.  It  occurs 
as  white  crystals  that  are  only  slightly  soluble  in  water  or  glycerin, 
but  readily  soluble  in  alcohol.  The  solution  in  alcohol  is,  however, 
readily  decomposed  by  water.     {Phar.  Zeniralh.,  1907,  page  192.) 
Coryfin  is  a  menthol  ester  of  ethylglycolic  acid.  It  is  a  colorless 
and  odorless  liquid,  very  slightly  soluble  in  water,  and  readily  soluble 
in  alcohol,  ether  and  chloroform.  It  is  neutral  in  reaction  and  leaves 
no  residue  on  heating.  Coryfin  is  used  internally  as  an  intestinal 
antiseptic  and  externally  as  an  application  for  securing  the  anesthetic 
and  analgesic  action  of  menthol.    (Apothek.,Zeitg.y  1907,  page  494.) 
Euscopol  is  said  to  be  the  hydrobromide  of  scopolamine  that  is 
optically  inactive  and  free  from  foreign  alkaloids.  It  melts  at  180 
to  1810.    (Chem.  and  Drug.,  1907,  page  837.) 
Formidin  This  is  said  to  be  an  iodide  of  methylene  disalicylic 
acid,  produced  by  the  condensation  of  formaldehyde,  salicylic  acid 
and  iodine.  It  is  recommended  for  internal  use  and  also  as  a  dusting 
powder  for  wounds  in  place  of  iodoform. 
Zernik,  in  a  recent  number  of  the  Apotheker  Zeitung  (1907,  page 
383),  states  that  quantitative  analysis  showed  that  the  substance 
does  not  conform  to  the  published  formula,  but  contains  about  20 
per  cent,  less  iodine.  Additional  tests  failed  to  show  the  separation 
of  formaldehyde  in  presence  of  either  acids  or  alkalies. 
Metramin. — This  is  another  recent  addition  to  the  already 
numerous  proprietary  names  for  the  official  hexamethylenamine. 
(Phat.  Zeilg.,  1907,  page  541.) 
MonotoL — This  was  formerly  the  ethyl  glycollic  acid  ester  of 
guaiacol,  but  the  manufacturers  are  now  marketing  the  correspond- 
ing methyl  ester  under  the  same  name,  which  is  a  liquid  at  o°  C. 
The  original  compound  was  a  white  crystalline  mass  at  300  C. 
{Pharm.  Zentralh.,  1907,  page  666.) 
