THERAPEUTICAL  PROPERTIES  OF  SANGUINARINA,  ETC.  139 
easiness  in  the  stomach  after  the  second  dose,  which  increased 
to  nausea  after  the  third  and  fourth  doses.  In  each  case  the 
pulse  was  reduced,  but  the  reduction  appeared  to  be  owing 
quite  as  much  to  the  nausea  as  to  any  positive  sedative  effect  of 
the  remedy  upon  the  heart. 
Experiments  with  the  Sulphate  of  Sanguinarina, 
Having  obtained  by  the  previous  trials  a  knowledge  of  the 
proper  quantity  to  be  administered,  I  placed  in  the  hands  of 
Mr.  B.  L.  Bird,  one  of  the  Resident  Physicians  of  the  Episcopal 
Hospital,  some  of  the  sulphate,  which  he  gave  to  a  number  of 
the  patients,  carefully  watching  the  results. 
He  exhibited  the  remedy  in  doses  ranging  from  one-tenth  to 
one-half  of  a  grain  every  three  hours.  In  no  case  had  we  rea- 
son to  think  that  it  acted  on  the  bowels,  kidneys,  or  skin. 
When  given  in  doses  of  one-tenth  to  one-sixth  of  a  grain, 
nearly  all  of  the  patients  could  take  it  every  three  hours  for  one 
or  two  day3  without  experiencing  nausea  or  much  gastric  un- 
easiness ;  and  in  every  case  but  two  the  pulse  was  reduced  five 
to  ten  beats  in  the  minute,  after  the  patient  had  taken  it  36  to 
48  hours. 
In  one  case,  three  doses  of  a  quarter  of  a  grain  each  were 
given  at  intervals  of  two  hours.  After  each  dose  the  patient 
experienced  warmth  in  the  stomach  and  nausea.  The  last  dose 
was  followed  by  vomiting.  The  reduction  of  a  few  beats  in  the 
pulse,  in  this  case,  was  probably  occasioned  by  the  sickness  of 
the  stomach. 
In  another  case  a  single  dose  of  a  quarter  of  a  grain  pro- 
duced nausea  and  slight  vomiting.  Half  a  grain  was  adminis- 
tered to  another  patient  as  an  emetic,  and  the  dose  was  repeated 
in  fifteen  minutes.  Prompt  and  free  vomiting  occurred  soon 
after  the  second  dose,  without  undue  retching  or  distress. 
The  following  is  a  convenient  mode  of  exhibiting  the  sulphate 
in  solution  as  an  expectorant : 
g..  Sanguinarinse  sulphatis,  gr.  j. : 
Aquae,  fej. 
Solve  et  adde 
Syrupi,  fexv. 
M. 
Signa.    Dose,  a  teaspoonful. 
