SOURCE  OF  SULPHUR. 
141 
several  of  the  patients  slept  better  at  night,  but  this  seemed  to 
be  due  more  to  the  relief  of  the  cough  than  to  a  specific  narcotic 
action  of  the  drug. 
As  the  result  of  the  various  experiments  above  alluded  to,  and 
partly  described,  I  think  the  following  conclusions  may  be  con- 
sidered established,  viz.  : — That  Sanguinaria  and  its  salts,  when 
given  in  doses  ranging  from  one-twelfth  to  one-eighth  of  a  grain, 
act  as  an  expectorant,  promoting  the  discharge  of  the  mucus 
from  the  lungs  without  disordering  the  stomach  to  any  consid- 
erable extent. 
When  given  in  quantities  of  one-sixth  to  one-fourth  of  a  grain 
at  intervals  of  two  or  three  hours,  most  persons  experience 
nausea  after  each  dose,  and  some  actually  vomit. 
If  half  a  grain  be  given  in  solution  every  ten  minutes,  vomit- 
ing will  almost  certainly  ensue  after  the  second  or  third  dose. 
If  the  eighth  or  the  sixth  of  a  grain  be  given  every  three 
hours  for  two  or  more  days,  the  pulse  will  generally  be  reduced 
from  five  to  fifteen  beats  in  a  minute,  thus  showing  a  decided 
sedative  impression  on  the  heart,  which  impression,  however,  is 
slowly  developed,  and  ceases  soon  after  the  medicine  is  discon- 
tinued. The  reputed  effects  of  bloodroot  upon  the  liver,  and  as 
an  alterative,  have  not  been  produced  by  sanguinarina  or  its  salts 
upon  myself  or  others  subjected  to  experiment.  The  alkaloid 
sanguinarina  is  certainly  the  most  valuable  principle  existing  in 
the  bloodroot,  but  I  am  persuaded  it  is  not  the  sole  agent,  as 
some  trials  made  with  the  impure  resin  show  that  the  latter  also 
possesses  nauseant  and  emetic  properties. 
Proc.  Am.  Pharm.  Assoc.,  1864. 
SOURCE  OF  SULPHUR. 
Until  within  the  last  few  years  Sicilian  sulphur  was  almost  ex- 
clusively employed  in  this  district  for  the  manufacture  of  sul- 
phuric acid — the  pyrites  from  Wicklow  being  the  only  other 
source  of  supply.  This  latter,  however,  was  not  sufficiently 
abundant  to  render  the  manufacturer  independent  of  the  great 
fluctuations  which  have  recently  taken  place  in  the  price  of  sul- 
phur, on  account  of  the  demand  consequent  on  the  vine  disease. 
During  the  la?.t  fe^Y  years  the  following  additional  sources  of  sup 
