Am" May'  fji""1"  }  Tablets  Contains  Salol  and  Quinine  Sulphate.  215 
pute  the  quantity  of  U.  S.  P.  quinine  sulphate,  after  making  tests 
upon  the  residue  to  prove  that  it  is  quinine  sulphate. 
Fluid  Extract  Belladonna.5 — Powder  50  weighed  tablets,  add  3 
mils  of  3%  sulphuric  acid6  and  12  mils  of  distilled  water,  warm 
for  about  one  hour  at  about  400  C,  filter,  make  filtrate  neutral  to 
litmus  paper  by  addition  of  -f^  sodium  hydroxide. 
To  .9  of  a  mil  of  the  neutralized  filtrate  add  .1  of  a  mil  of  salt 
solution.7 
Introduce  two  drops  of  this  solution  into  a  cat's  eye8  every  five 
minutes  until  a  total  of  six  drops  have  been  introduced. 
The  pupil  of  the  cat's  eye  should  show  a  dilation  after  an  elapse 
of  one  hour  if  the  sample  contains  fluid  extract  of  belladonna.9  If, 
however,  there  is  no  dilation  of  the  pupil  noticeable  after  an  elapse 
of  one  hour,  it  is  advisable  to  try  another  cat,  and  introduce  a  total 
of  eight  drops  over  a  period  of  twenty  minutes.  The  cat's  eye  should 
be  observed  every  half  hour  until  an  elapse  of  about  five  hours. 
Chemical  Laboratory, 
Department  of  Health, 
New  York  City. 
ANALYSIS  OF  TABLETS  CONTAINING  SALOL  AND 
QUININE  SULPHATE. 
By  Reginald  Miller. 
Salol. — Weigh  twenty-five  tablets  and  powder  them,  take  of  the 
well-mixed  powder  a  portion  corresponding  to  the  average  weight 
of  one  tablet.  Transfer  to  a  small  beaker,  add  an  equal  volume  of 
clean  sand.1 
5  This  is  detected  by  qualitative  test. 
6  There  must  be  a  slight  excess  of  acid  present;  test  with  litmus  paper 
and  if  not  acid,  add  more  until  it  is. 
7  The  salt  solution  is  made  by,  dissolving  one  G.  of  sodium  chloride  in  100 
mils  of  distilled  water. 
8  After  each  introduction  of  the  solution  in  the  cat's  eye,  the  membrane 
surrounding  the  eye  should  be  gently  closed  and  opened  in  order  to  aid  the 
absorption.  Care  must  also  be  taken  that  none  of  the  fluid  gets  into  the  cat's 
mouth  or  nose. 
9  The  dilation  begins  in  about  forty-five  minutes  and  is  very  pronounced 
after  an  elapse  of  one  hour. 
1  Sand  seems  to  facilitate  the  extraction. 
