44-0  Specificity  of  Drugs  for  Phosphatids.  {* 
Table  IV. 
Heart  Lecithin  C,  0.3  Per  Cent. 
CaCU  to  ppt. 
Control. 
Diff.  in  CaCfe. 
.0097 
.OO97 
.0 
nitrate  
.0114 
.OO97 
+  .0017 
sulfate  
.0114 
.0097 
+  .0017 
acetate   
•OI23 
.OO97 
+  .0026 
Other  alkaloids  gave  similar  differences  also.  Of  course,  these 
differences  must  be  due  to  the  direct  action  of  the  negative  radicle 
on  the  lipin.  This  data  shows  the  necessity  of  working  with  the 
alkaloids  themselves  if  comparable  results  are  to  be  obtained.  It 
indicates,  too,  that  small  amounts  of  impurities  affect  rather  largely 
the  results  obtained.  Some  of  the  variations  found  in  different 
preparations  might  be  attributed  to  this  cause.  It  might  be  said 
that  the  results  obtained  were  due  to  impure  drugs.  Though  the 
compounds  used  were  not  purified,  they  were  the  best  obtainable 
on  the  market.  One  would  not  expect  the  consistent  data  obtained 
if  these  impurities  were  related  so  definitely  to  the  results.  In  the 
organism,  however,  the  different  salts  would  not  produce  changes 
similar  to  those  recorded  above  because  the  drug,  no  matter  in  what 
form  it  was  administered,  would  arrive  at  the  cell  in  the  same  form. 
Concentration  of  Drugs. — It  was  desirable  to  know  what  was 
the  effect  of  differing  drug  concentrations  upon  the  lipins. 
Table  V. 
Heart  Lecithin,  0.3  Per  Cent. 
1   CaCU  in  ppt. 
Control. 
Diff.  in  CaCl2. 
1/1000  strophanthin  
  .0052 
.OO44 
+  .0008 
1/2000   
  .0048 
.OO44 
+  .0004 
1/4000  "   
. :   .0046 
.OO44 
+  .0002 
1/8000  "   
  .0044 
.0044 
.0 
With  an  increase  in  amount  of  drug  the  difference  in  amount  of 
CaCl2  necessary  to  precipitate  the  lecithin  increased.  This  fact  is 
consistent  with  the  larger  effects  produced  by  increased  amounts 
of  drug  and  so  would  indicate  that  the  lipins  are  concerned  in  the 
relation  between  drug  concentration  and  amount  of  pharmacological 
effect  produced. 
Cuorin  and  Cephalin. — If  brain  lecithin  and  heart  lecithin  do 
