492  Antiseptics  and  the  War.  { K$J°™^™\ 
kept  for  about  a  month  before  any  noticeable  loss  is  apparent,  while 
with  chlorinated  paraffin  oil  as  part  of  the  formula,  the  permanence 
of  the  antiseptic  is  considerably  shortened.  The  only  reason  for 
using  the  paraffin  oil  is  to  cheapen  ,the  cost  of  the  end  product. 
Application  of  this  germicide  is  made  by  spraying  the  wound 
with  the  oily  solution  and  applying  as  a  covering  a  few  strips  of 
gauze.  The  slow  but  persistent  action  of  the  oily  antiseptic  prepara- 
tion necessitates  a  change  of  dressing  only  once  a  day,  a  property 
which  will  perhaps  hasten  the  increase  of  its  use  as  compared  with 
Dakin's  fluid. 
Chloramin-T,  chlorinated  eucalyptol,  and  all  of  the  other  Dakin 
preparations  are  now  manufactured  and  marketed  in  this  country. 
The  following  formulas  for  preparing  Chloramin-T,  Chlorinated 
Eucalyptol,  and  Chlorinated  Paraffin  Oil  were  given  by  Dr.  R.  G. 
LeConte  in  an  article  read  by  him  before  the  American  Surgical 
Association,  at  Boston,  June  2,  1917. 
For  the  Preparation  of  T  oluene-P  arasulphondichloramin  or  Di- 
chloramin-T  (Chattaway's  method). 
Take — 
Chlorinated  Lime  (good  quality)    350  to  400  Gm. 
Water    2  Liters 
Chloroform  1     -  .  . 
.      .     .  .  ,  U  about  100  mils  of  each 
Acetic  Acid   J 
Toluene-parasulphonamid    75  Gm. 
Add  the  chlorinated  lime  to  the  water  and  shake  for  half  an  hour 
and  allow  the  mixture  to  settle.  Siphon  off  the  supernatant  liquid 
and  filter  the  remainder.  Dissolve  the  powdered  toluene-parasul- 
phonamid in  the  filtrate  and  filter  if  necessary.  Place  this  mixture 
in  a  separatory  funnel  and  gradually  acidify  with  acetic  acid.  Add 
100  mils  of  chloroform  and  extract  the  dichloramin.  Remove  the 
chloroform  layer  and  allow  the  solution  to  evaporate  spontaneously. 
Dry  the  residue  in  vacuo  and  powder. 
For  the  Preparation  of  Chlorinated  Eucalyptol. 
Take— 
Eucalyptol,  U.  S.  P   500  mils 
Potassium  Chlorate    15  Cm. 
Hydrochloric  Acid,  U.  S.  P   50  mils 
Mix  all  three  and  allow  them  to  interact  for  about  12  hours. 
Wash  well  with  water  either  by  decantation  or  in  a  separatory 
