Am.  Jour.  Pharm.  | 
November,  1917.  ' 
Antiseptics  and  the  War. 
493 
funnel.  Then  wash  with  sodium  carbonate  solution.  Add  anhy- 
drous sodium  carbonate  and  allow  this  to  remain  there  for  24  hours. 
Filter  and  dry  over  calcium  chloride. 
For  the  Preparation  of  Chlorinated  Paraffin  Oil. 
Expose  the  mixture  to  the  light  and  then  allow  it  to  stand  over 
night.  Wash  it  in  a  separatory  funnel  successively  with  water,  salt 
solution,  and  finally  with  water.  Add  a  few  pieces  of  calcium 
chloride  and  5  Gm.  of  purified  charcoal  and  filter  with  suction. 
Doctors  Dufrasne,  Vincent  and  others,  at  present  at  the  Allies' 
front,  have  been  using  a  chloramin-T  paste,  both  for  maintaining 
asepsis  of  a  wound  and  for  sterilizing  infected  parts.  The  paste, 
which  appears  as  a  snow-white  cream,  is  sufficiently  active  to  be  used 
effectively  but  begins  to  loose  its  activity  in  about  a  month  after 
preparation. 
The  following  is  a  formula  of  the  paste  used  by  Dr.  Dufrasne 
and  published  in  the  July  issue  of  the  Journal  of  Experimental 
Medicine. 
Chloramin-T  Paste. 
Chloramin-T    5  to  20  Gm.  (or  the  desired  quantity) 
To  one  liter  of  boiled  water,  add  the  stearic  acid.  When  the 
latter  has  melted,  add  enough  caustic  soda  to  saponify  all  of  the 
fatty  acid.  After  complete  solution,  add  the  chloramin-T  to  give  a 
product  of  the  desired  strength.  Shake  and  finally  stir  the  mixture 
until  it  has  congealed. 
Chlorazene. — Another  Dakin  product  is  similar  to  dichlor- 
amin-T,  being  the  sodium  salt  of  para-toluenesulphochloramin.  In 
some  of.  the  hospitals,  the  two  antiseptics  have  been  used  in  con- 
junction, first  spraying  and  thoroughly  cleansing  the  wound  with  an 
aqueous  solution  of  chlorazene  and  then  applying  the  oily  solution 
or  paste  of  dichloramin. 
Halazone. — Another  problem  which  the  war  brought  forth  was 
Take- 
Paraffin  Oil  
Potassium  Chlorate 
Hydrochloric  Acid 
500  mils 
15  Gm. 
50  mils 
Stearic  Acid   
Sodium  Hydroxide 
Water   
1  Liter 
