AmjJa0n"r,x8P7h8arm*}         Fluid  Extract  of  Cimicifuga.  3 
cimicifuga  contained.  A  half-inch  glass  tube  was  drawn  at  the  bot- 
tom like  a  syringe,  and  plugged  with  a  wad  of  cotton.  438  grains  of 
powdered  cimicifuga  was  moistened  with  alcohol,  and  carefully  and 
firmly  pressed  into  the  tube  ;  the  powder  was  covered  with  a  closely 
fitting  paper,  and  alcohol  added  from  a  self-regulating  supply-vessel 
until  112  fluidounces  had  passed. 
One  cc,  carefully  evaporated  in  watch  glass,  gave     .  .  .       '018  grain 
Total  yield  of  1 12  fluidounces,  .....    59*51  " 
The  powder  was  removed  from  the  tube,  dried,  rubbed  in  a  mortar, 
and  again  moistened  with  alcohol  and  replaced  in  the  tube  ;  alcohol 
supplied  until  64  fluidounces  had  passed. 
One  fluid  dram  yielded  *oi  grain  dry  extract. 
Total  yield  of  64  fluidounces,        .....         5*12  grains 
Total  amount  extracted  from  438  grains  of  powdered  cimicifuga 
by  176  fluidounces  of  alcohol,  .....  64*63  " 
One  troyounce  will  contain  .....       70*83  " 
7680  grains  (16  troyounces),  .....    1133*26  " 
About  14!  per  cent.  , 
The  extraction  of  the  resin  from  the  powder  may  not  have  been 
absolute,  but  I  think  the  operation  was  carried  as  far  as  could  be 
desired.  The  first  percolate,  112  fluidounces,  was  deep  straw-color, 
the  second  very  light. 
I  assume  that  if  a  fluid  extract  of  cimicifuga  represents  the  amount 
of  powder  employed,  each  portion  of  16  fluidounces  will  contain 
1 133*26  grains  of  dry  extractive  matter,  soluble  in  strong  alcohol,  and 
the  ratio  between  the  number  of  grains  actually  contained  and  1133*26 
represents  the  value  of  the  fluid  extract  as  compared  with  what  it 
should  be. 
Experiment  1,  U.  S.  P. — 7,680  grains  powdered  cimicifuga,  properly 
moistened  and  pressed  into  a  cylindrical  tube,  three  inches  internal 
diameter,  filled  it  ten  inches  in  height.  I  had  ten  tubes  constructed, 
of  such  diameter  that  the  first  would  allow  7,680  grains  to  stand 
fifteen  inches  high  ;  the  second  required  twice  7,680  grains  ;  the  third 
three  times  7,680,  and  so  on  until  the  tenth  required  ten  times  7,680, 
the  powder  in  each  of  the  ten  percolators  occupying  fifteen  inches  in 
height.  The  tubes  were  thirty-six  inches  long.  To  arrive  at  these 
sizes,  I  calculated  the  number  of  cubic  inches  the  tube  three  inches  in 
diameter  and  ten  inches  long  contained  (70*68),  and  from  these  known 
terms  arrived  at  the  diameter  of  the  percolators  (see  tables). 
