4  Fluid  Extract  of  Cimicifuga.  {^jZZ'JSF* 
Moveable  diaphragms  were  made  of  perforated  tin  ;  they  were  cov- 
ered with  muslin  and  so  arranged  as  to  rest  at  the  bottom  of  each  tube, 
nicely  fitting  into  each.  A  round  piece  of  filtering-paper  was  placed 
over  them.  Below  the  diaphragms  the  percolators  tapered,  funnel- 
shaped,  to  a  small  tube,  where  was  attached  a  stop-cock.  Commenc- 
ing at  the  smallest,  the  ten  percolators  were  arranged,  in  natural  order, 
in  a  frame. 
7,680  grains  of  powdered  cimicifuga  was  moistened  with  4  fluid- 
ounces  of  strong  alcohol,  and  pressed  into  the  smallest  percolator  ;  the 
powder  occupied  15  inches  in  height.  The  operation  was  repeated 
until  7,680  grains  had  been  pressed  into  each  of  the  ten,  the  powder 
being  made  to  occupy  a  proportional  less  height  as  the  diameter  of  the 
percolator  increased.  To  reduce  the  powders  to  the  height  desired,  I 
used  cylindrical  boards  which  accurately  fitted  each  percolator,  they  were 
attached  to  graduated  handles.  Circular  papers  were  placed  over  each 
powder,  and  held  in  place  with  pieces  of  perforated  tin.  The  remainder 
of  16  fluidounces  of  alcohol  was  then  poured  upon  each  powder,  the 
percolators  covered  with  panes  of  glass  and  allowed  to  macerate  four 
days.  At  the  end  of  this  time  no  liquid  appeard  at  the  exit  tube  of 
any  percolator.  33  fluidounces  of  alcohol  were  then  added  (16  troy- 
ounces  of  powdered  cimicifuga  will  absorb  and  hold  from  24  to  25 
fluidounces  alcohol). 
TABLE  1. 
Amount  of  powder 
in  each  percolator. 
Diameter  of  perco- 
lator. 
Height  of  powder. 
Am't  of  dry  ext  ve 
matter  cont'd  in 
1  cc.  of  the  per- 
colate, 14  floz. 
Total    amount  of 
extractive  matt'r 
in  14  floz. 
Amount  of  dry  ex- 
tractive matter 
cont'd  in  i  cc.  of 
the  percolate,  10 
floz. 
Total  dry  extrac- 
tractive  matter 
in  10  floz.  perco- 
late. 
Total  am't  of  dry 
extractive  matt'r 
in  the  finished 
fluid  extract. 
Finished  fluid  ex- 
tract represents 
powdered  Cimi- 
cifuga. 
Grains. 
Inches. 
Inches. 
Grains. 
Grains. 
Grains. 
Grains. 
Grains. 
Grains. 
7680 
2*45 
15' 
r4i 
582-72 
•18 
53  H 
635  86 
4309  16 
7680 
3'46 
rs 
1  25 
516  60 
•42 
123-98 
640-58 
434i'I5 
7680 
4-24 
5' 
•85 
351*29 
•76 
224-35 
575'64 
3901-06 
7680 
4'9° 
375 
75 
309*96 
•66 
i94*83 
504*79 
3420-92 
7680 
584 
3* 
•81 
334  76 
•55 
162-36 
497*12 
3368-94 
7680 
6- 
2'5 
•70 
289-30 
*53 
156-46 
445*76 
3020-82 
7680 
6-48 
2-14 
•62 
256-23 
•66 
194*83 
451-06 
3056*79 
7680 
693 
r88 
•85 
35i*29 
"53 
156*46 
507'75 
3440-98 
7680 
7*35 
1*67 
'57 
235*57 
'44 
129-89 
365*46 
2476*67 
7680 
775 
i'5 
•86 
355*42 
'42 
123*98 
479*4o 
3248-85 
76800 
3583*14 
152028 
5103-42 
34585*34 
