8  Fluid  Extract  of  Cimicifuga.        { ^'^J^ 
I  come  now  to  the  third  experiment,  where  the  plan  recommended 
in  the  U.  S.  D.,  page  1164  (note),  for  cinchona  was  applied  to  cimici- 
fuga,  the  operation  being  suspended  when  the  official  amount  of  per- 
colate was  obtained. 
Experiment  3. — Ten  portions,  each  7,680  grains  of  powdered  cimici- 
fuga,  were  intimately  mixed,  each  separately,  with  32  fluidounces  of 
alcohol,  and  allowed  to  macerate  30  minutes,  when  each  portion  was 
transferred  to  a  percolator — the  ten  percolators  being  those  before  used. 
When  the  liquid  disappeared  below  the  surface  of  the  powder,  alcohol 
was  added  until  a  sufficient  amount  of  percolate  had  been  obtained,  said 
percolates  being  reserved  in  portions  each  of  14  and  10  fluidounces. 
The  fluid  extract  was  completed  according  to  the  directions  of  the  U. 
S.  P.    See  table  3. 
TABLE  3. 
Amount  of  powder 
in  each  percolator. 
Height  of  powder 
in  each  percola- 
tor. 
Diameter  of  perco- 
lator. 
Am't  of  dry  extr't 
contained  in  i  cc. 
of  the  percolate, 
14  floz. 
Total    extract  in 
14  floz. 
Am't  of  dry  extr't 
contained  in  i  cc. 
of  the  percolate, 
10  floz. 
Total  dry  extract 
in  10  floz. 
Total  am't  of  dry 
extractive  matt'r 
in    the  finished 
fluid  extract. 
Finished  fluid  ex- 
tract represents 
powdered  Cimi- 
cifuga. 
Grains. 
Inches. 
Inches. 
Grains. 
Grains. 
Grains. 
Grains. 
Grains. 
Grains. 
7680 
15" 
2 '45 
•72 
297-56 
•74 
218-45 
516-01 
349685 
7680 
7  5 
3"46 
•71 
293-43 
•70 
206-64 
500-07 
3388  93 
7680 
5' 
4-24 
•76 
3M09 
•52 
i53'50 
4°7'59 
3168  81 
7680 
375 
4-90 
•66 
272*76 
•50 
147  60 
420*36 
2848-74 
7680 
3" 
5-48 
'71 
293'43 
•57 
168-26 
461-69 
3128-83 
7680 
2'5 
6- 
•64 
264-50 
*59 
174-17 
438  67 
2972*83 
7680 
2  14 
648 
•68 
281*03 
•58 
171-22 
452*25 
3064-86 
7680 
r88 
6  93 
•70 
289-30 
•60 
177-12 
466-42 
3160-89 
7680 
167 
7'35 
•74 
305-83 
•52 
i53'5° 
459'33 
3112*84 
7680 
i'S 
7"  75 
63 
260*37 
•48 
141-70 
402-07 
2724-79 
76800 
2872*30 
1712-16 
4584-46 
31068-37 
Although  the  maceration  is  continued  only  30  minutes,  it  strikes  me 
the  process  may  better  be  called  percolation  with  maceration,  than  that 
of  the  U.  S.  P.  A  marked  peculiarity  of  the  result  of  the  ten  experi- 
ments is  the  regular  amount  of  extractive  matter  contained  in  the  fluid 
extracts  ;  but  while  there  is  more  certainty  as  to  the  regularity  of  the 
extracts  made  by  this  method,  judging  from  these  experiments,  each 
