i4 
Fluid  Extract  of  Cimicifuga. 
(  Am.  Jour.  Pharntu 
(      Jan.,  1878. 
by  the  repercolation  process,  and  10  by  simple  percolation,  being  a 
difference  of  1 1  per  cent,  in  favor  of  simple  percolation. 
10 J  fluidounces  of  percolate,  the  third  reserved  portion  by  reperco- 
lation, I  represent  as  corresponding  with  the  first  percolate — simple 
percolation — because  this  is  the  only  fraction  which  passes  through  the 
entire  24  troyounces  of  powder  by  the  repercolation  process,  but  it 
should  be  remembered  that  16  troyounces  have  been  submitted  to  the 
action  of  two  previously  reserved  portions,  consequently  it  must  not 
be  expected  that  an  equal  amount  of  matter  will  be  extracted  by  the 
two  percolates,  and  a  comparison  of  results  shows  that  the  repercola- 
tion fraction  contains  less  than  percolation  by  204.57  grains.  The 
second  percolate,  7J  fluidounces,  passes  in  the  repercolation  process 
through  8  troyounces  of  powder,  which  have  not  been  submitted  to 
the  action  of  any  previous  percolate,  also  through  8  troyounces,  which 
have  been  partly  extracted  by  the  reserved  percolate  (6fg).  The  cor- 
responding fraction  in  simple  percolation  passes  through  24  ounces  of 
cimicifuga,  all  of  which  has  been  partly  exhausted  by  the  preceding 
percolate,  the  result  shows  us  that  this  fraction  contains  13*30  grains 
more  extractive  matter  in  the  simple  percolation  process. 
The  other  reserved  portion,  6  fluidounces,  is  the  first  by  the  reperco- 
lation process,  and  is  actually  simple  percolation  where  the  first  6 
fluidounces  of  a  percolate,  from  8  troyounces  of  cimicifuga,  are 
reserved.  By  simple  percolation  the  corresponding  percolate  is  the 
last,  and  passes  through  24  troyounces  of  cimicifuga,  which  have  been 
depleted  to  a  large  extent  of  soluble  materials  by  the  action  of  two 
preceding  percolates,  (reserved  as  two).  It  is  seen  that  this  percolate 
contains  113*36  grains  less  by  simple  peercolation  than  by  repercola- 
tion, but  the  excess  of  extractive  matter  contained  in  the  first  two 
portions,  in  favor  of  simple  percolation,  makes  the  total  result  104. 51 
grains  in  favor  of  that  process. 
In  the  preceding,  I  have  illustrated,  by  seven  tables,  my  experience 
with  four  different  processes  for  making  fluid  extract  of  cimicifuga, 
embracing  34  experiments.  The  following  table  (No.  8)  gives  the 
value  of  the  best  fluid  extract  of  each  process. 
