226  Fluid  Extracts  by  Reper eolation.      \  AmMJa°yu)r;8p78arm* 
might  follow  him.  It  is  regretted  that  he  did  not  refer  to  later  papers 
on  the  subject  of  percolation  and  repercolation, — or  at  least  did  not 
adopt  some  important  modifications  that  are  published  in  later  papers. 
His  work  upon  Cimicifuga  has  been  repeated  by  precisely  the  same 
method  as  given  above  for  Cinchona, — that  is  in  accordance  with  the 
.ater  experience  on  percolation  and  repercolation, — and  the  results  are 
given.  Those  who  will  compare  these  results  with  those  of  Mr. 
Lloyd  will  find  important  discrepancies  which  must  belong  to  one  set 
of  observations  or  the  other.  On  one  important  point  Mr.  Lloyd  must 
reach  a  wrong  conclusion,  for  it  certainly  can  be  demonstrated  upon 
well  known  physical  laws,  that  maceration  to  a  proper  extent  is  useful 
and  necessary  to  other  conditions  of  the  problem.  This  point  is  so 
well  established  by  general  experience  that  this  part  of  his  work  was 
riot  gone  over.  The  formula  and  process  adopted  here  were  as  follows  : 
Take  of  Cimicifuga,  in  powder  No.  60,        .  .    32  parts. 
Stronger  Alcohol,  s.  g.  "819  at  i5*6°C=6o°F, 
or  s.  g.  *8n  at  25°C.=77°F.,  a  sufficient  quantity. 
Moisten  8  parts  of  the  Cimicifuga  with  2  parts  of  the  Alcohol,  and 
pack  it  firmly  in  a  percolator.  Then  pour  Alcohol  on  top  until  the 
moist  powder  is  thoroughly  filled  with  liquid  and  the  air  is  forced  out, 
cover  the  percolator  and  macerate  for  48  hours.  Then  arrange  the 
percolator  for  an  automatic  supply  of  menstruum,  and  start  the  per- 
colation at  such  a  rate  as  to  give  about  one  part  of  percolate  every  three 
hours.  Reserve  the  first  6  parts  of  percolate,  and  continue  the  per- 
colation to  practical  exhaustion,  receiving  the  weaker  percolate  on 
separate  portions  of  about  4  parts  each. 
Then  moisten  a  second  portion  of  8  parts  of  the  Cimicifuga  with  2 
parts  of  the  second  percolate  from  the  first  portion  of  powder,  pack  it 
firmly  in  a  percolator,  and  supply  it  on  top,  first  with  the  remaining 
2  parts  of  the  second  percolate  from  the  first  portion,  and  then  with 
the  successive  weak  percolates  in  the  order  in  which  they  were  obtained, 
until  the  moist  powder  is  entirely  filled  with  liquid.  Then  macerate 
for  48  hours,  and  percolate  to  practical  exhaustion  at  the  same  rate  as 
in  the  first  portion  of  the  Cimicifuga,  using  first  the  weak  percolates 
in  their  proper  order,  and  then  fresh  menstruum.  Reserve  the  first  8 
parts  of  percolate,  and  receive  the  weak  percolate  in  separate  portions 
of  about  4  parts  each. 
