Am jine" i?;1?"11, }  Gleanings  from  the  German  Journals ,  297 
addition  of  more  hydrochloric  acid,  is  shaken  three  times  with  15  or 
20  cc.  of  chloroform  ;  the  chloroform  extractions  are  washed  with 
water  and  distilled  to  dryness  ;  the  residue  is  dissolved  in  very  little 
soda-lye,  filtered  if  necessary,  and  the  filter  washed  with  a  little  water. 
The  solution  is  then  strongly  acidulated  with  hydrochloric  acid  and  set 
aside  in  a  cool  place.  Two  or  three  days  later  the  santonin  may  be 
collected  on  a  filter,  washed  with  10  or  15  cc.  of  8  per  cent,  soda  solu- 
tion, and  after  drying  at  uo°C,  weighed.  For  every  10  cc.  of  aque- 
ous liquid,  from  which  the  santonin  was  precipitated  (not  counting  the 
wash  water),  there  may  be  added  to  the  weight  of  the  santonin  *002 
grm.,  and  for  every  10  cc.  of  soda  solution  used  for  washing  '003  grm. 
— Archiv  d.  Pharm.,  April,  p.  306. 
Salicylate  of  Sodium. — A.  Bernick  prepares  a  solution  containing 
one-third  of  its  weight  of  this  salt  by  mixing  84  parts  of  bicarbonate  of 
sodium  with  200  p.  of  distilled  water,  and  neutralizing  without  heat  by 
138  p.  of  purified  salicylic  acid  The  resulting  solution  is  nearly  color- 
less, and  remains  unchanged  if  kept  in  black  bottles. — Pharm.  Ztg., 
April  10. 
Antidote  to  Carbolic  Acid. — On  the  recommendation  by  Prof. 
Baumann,  Dr.  Sanftleben  used  sulphuric  acid  in  several  cases  of  poison- 
ing by  carbolic  acid  with  the  best  success,  the  phenol  combining  with 
the  acid  to  phenyl-sulphuric  acid,  which  is  not  poisonous.  He  admin- 
istered it  in  a  mixture  composed  of  dilute  sulphuric  acid  iO'O,  mucilage 
of  gum  200*0,  and  simple  syrup  30*0  grams,  in  doses  of  a  tablespoonful 
every  hour. — Pharm.  Ztg.  f.  RussL,  Feb.  15,  p.  119,  from  Milk. 
Ztschr. 
The  Dose  of  Caffeina. — According  to  Nothnagel's  "Arzneimit- 
tellehre,"  citrate  and  lactate  of  caffeina  are  usually  given  in  Germany 
in  doses  of  '05  to  *i  gram,  but  French  physicians  commence  with  doses 
of  -5  and  increase  the  dose  to  2*0  and  even  4*0.  Dr.  Kelp  repeatedlv 
gave  doses  of  *I2  gram  four  times  daily  without  apparent  injurious 
effects,  and  Dr.  Wolff  states  the  dose  in  migrana  to  be  *2  to  '\  gram 
several  times  a  day. — Pharm.  Ztg.,  April  6. 
Test  for  Impurities  in  Tannate  of  Q  uinia. — After  numerous 
experiments,  Julius  Jobst  recommends  to  proceed  as  follows:  1  gram 
of  quinia  tannate  is  powdered,  well  mixed  with  freshly-slaked  lime 
and   the  mixture  dried   in  a  water-bath.     The  resulting  powder  is 
