Am.  Jour.  Pharm  ) 
Sept.,  1878.  j 
Fluid  Extract  of  Cimicifuga. 
437 
senting  the  powder  operated  upon.  At  the  fifteenth  ounce,  the 
cheapest  point  in  the  entire  process,  we  represent  nine  and  fifty  three 
hundredths  troyounces  of  powder.  The  sixteenth  ounce  adds  but  ten 
and  thirty-three  hundredths  grains  extract,  bringing  the  amount  to  nine 
and  sixty-eight  hundredths  ounces. 
The  decrease  in  extractive  matter  continues  till  the  twenty-first 
ounce  is  reached.  This  contains  the  same  as  the  twentieth  and 
twenty- third,  viz.:  six  and  forty- nine  hundredths  grains.  The  twenty- 
second  is  identical  in  amount  with  the  twenty-fourth. 
The  last  ten  fluidounces  of  the  percolate  only  add  eighty-six  and 
-seventeen  hundredths  grains  extractive  matter,  which  is  less  than  was 
contained  in  either  the  first  or  the  second  ounce  of  percolate.  It  only 
adds  one  and  twenty-two  hundredths  troyounce  of  cimicifuga,  to 
obtain  which  we  expend  eight  fluidounces  of  alcohol.  In  reality  it 
adds  two  fluidounces  to  the  fourteen  ounces  of  the  reserved  tincture, 
but  this  increase  of  bulk  is  deceptive,  inasmuch  as  it  dilutes  the  reserve. 
The  fourteen  fluidounces  of  reserved  tincture  contain  651*22  grains  of 
dry  extractive  matter,  an  average  of  forty-six  and  fifty  one  hundredths 
grains  to  each  fluidounce. 
The  two  ounces  of  evaporated  tincture  contain,  in  each,  but  forty- 
three  and  nine  hundredths  grains.  Consequently,  if  the  operation  had 
been  suspended  at  the  fourteenth  fluidounce  of  percolate,  each  ounce, 
without  the  use  of  heat,  would  have  represented  more  cimicifuga  than 
did  each  fluidounce  of  the  finished  extract.  The  expense  would  have 
been  less. 
Amount  of  cimicifuga  used  (see  table  10),  twenty-four  troyounces. 
Height  of  powder,  fifteen  inches.   Diameter  of  percolator,  three  inches. 
Moistened  with  six  fluidounces  of  alcohol.  Inserted  into  percolator 
and  prepared  for  percolation  like  the  preceding.  When  the  percolate 
appeared  one  fluidounce  was  obtained.  The  operation  was  suspended 
and  maceration  continued  sixteen  hours  at  temperature  ioo°F.,  when 
seven  ounces  were  run  off. 
Maceration,  in  like  manner,  was  again  continued  until  the  same  time 
upon  the  following  day.  Eight  fluidounces  were  then  procured.  In 
like  manner,  interrupted  percolation  was  employed  until  the  eighty 
fluidounces  of  the  percolate  had  been  obtained.  The  time  allowed 
was  thirty  minutes  to  each  fluidounce.     Eight  percolates  were  obtained 
