Am.  Jour.  Pharm. ") 
Oct.,  1878.  J 
Kinate  of  Quinia. 
487 
two  experiments  will  suggest  how  ammonium  salts  may  be  separated. 
When  fats  occur  they  must,  of  course,  be  removed  prior  to  treatment 
with  alkali. 
50  cc.  of  an  aqueous  solution  containing  1  per  cent,  each  of  ammo- 
nium chloride  and  glycerin,  were  evaporated  in  a  platinum  dish  over  a 
water-bath  to  dryness.  Saturated  solution  of  sodium  carbonate  was 
then  added,  and  the  heat  of  the  water-bath  continued  until  no  more 
ammoniacal  gas  was  evolved,  and  the  mixture  was  distinctly  alkaline. 
The  mixture  was  then  extracted  with  absolute  alcohol,  and  the  solution 
evaporated,  neutralized  and  tested.  The  green  color  was  distinctly 
seen. 
50  cc.  of  beer,  containing  1  per  cent,  each  of  ammonium  chloride 
and  glycerin  were  evaporated  to  dryness  over  a  water-bath.  The 
ammoniacal  salt  was  separated  from  the  residue  as  before.  The  mix- 
ture thus  obtained  was  treated  with  absolute  alcohol,  as  described  in  the 
paper,  and  tested,  the  final  solution  being  neutral,  or  only  faintly- 
alkaline.  The  green  flame  was  very  distinct.  50  cc.  of  beer  con- 
taining ammonium  chloride  only  were  examined  in  the  same  way,  but 
gave  no  green  color  to  flame. — 'Jour.  Chem.  So:.  [London],  Septem- 
ber, 1878. 
KINATE  OF  QUINIA  FOR  HYPODERMIC  INJECTION. 
By  Henry  Collier,  Guy's  Hospital. 
I  have  on  several  occasions  been  called  upon  to  make  a  solution  of 
quinia  for  hypodermic  injection,  and  as  the  ordinary  salts  of  quinia  (the 
sulphate  and  hydrochlorate)  are  not  very  soluble  in  water,  the  subject 
has  always  been  with  me  a  very  unsatisfactory  one. 
This  method  of  administration  is  desirable  when  the  patient  is  so 
constantly  sick  that  quinia  cannot  be  given  by  the  stomach,  and  in  such 
cases  the  principal  object  in  giving  the  remedy  is  to  reduce  temperature. 
Large  doses  are  also  required. 
Solutions  intended  for  hypodermic  use  require  to  be  neutral,  and  of 
such  a  strength  that  a  few  minims  only  are  needed  for  injection.  I 
have  prepared  a  solution  of  ordinary  quinia  sulphate,  containing  1  grain 
in  10  minims,  by  heating  the  quinia  and  water  in  a  beaker,  and  adding 
just  sufficient  dilute  sulphuric  acid  to  dissolve  the  quinia;  but  of  course 
the  solution  had  a  very  acid  reaction.  In  one  case,  however,  in  which 
this  was  employed,  the  patient  did  remarkably  well,  and  no  irritation 
