488 
Kinate  of  ghtinia. 
{Am.  Jour.  Pharm. 
Oct.,  1878. 
was  produced  by  the  punctures.  I  have  made  some  of  the  so-called 
neutral  sulphate  of  quinia,  but  even  after  a  second  crystallization  its 
solution  was  very  acid,  and  it  was  not  more  soluble  than  1  in  10. 
Hydrochlorate  of  quinia  is  fairly  soluble  in  warm  water,  and  such  a 
solution  has  been  injected  warm,  but  the  result  was  not  satisfactory. 
In  Parrish's  "  Practical  Pharmacy  "  it  is  stated  that  kinate  of  quinia  is 
soluble  in  4  parts  of  water,  and  a  process  is  given  for  its  preparation 
direct  from  cinchona  bark.  I,  however,  procured  from  Mr.  Morson 
some  kinate  of  calcium,  which  I  converted  into  barium  kinate.  This 
salt  is  freely  soluble  in  water,  and  upon  adding  to  its  solution  sulphate 
of  quinia,  in  powder,  the  whole  of  the  barium  is  precipitated  and  kinate 
of  quinia  remains  in  solution.  Upon  evaporation  the  kinate  comes  out 
in  amorphous  masses  ;  even  when  evaporated  under  the  air-pump  over 
H2S04,  the  same  result  is  obtained.  A  drop  of  the  same  solution  spread 
over  a  glass  slide  and  evaporated  slowly,  shows  under  the  microscope 
very  distinct  crystalline  tufts.  The  plan  I  adopt  is  to  reduce  the  solu- 
tion of  kinate  to  dryness  over  a  water-bath,  and  then  powder  the  residue. 
The  kinate  obtained  by  slow  evaporation  at  ordinary  temperatures  con- 
tains a  large  quantity  of  water,  some  of  which  it  loses  by  keeping  at 
90°F.,  so  that  to  insure  a  definite  product  it  is  necessary  to  dry  it. 
Kinate  of  quinia  is  very  soluble  in  water,  and  its  solution  is  perfectly 
neutral.  The  strength  of  the  solution  which  is  used  at  this  hospital  is 
1  in  4.  I  generally  prepare  %i  of  the  solution  at  a  time,  by  putting 
into  a  beaker  3vi  aq.  destil.  and  gii  kinate  of  quinia,  heating  until  the 
salt  dissolves,  which  it  does  almost  immediately,  and  then  making  up 
with  aq.  destil.  to  %\.  It  is  quite  possible  to  make  a  permanent  solu- 
tion containing  1  in  3,  but  I  find  that  1  in  4  is  more  convenient  for  use. 
Even  with  this  strength  the  syringe  requires  constant  washing  and  the 
solution  great  attention,  as  the  stopper  and  neck  of  the  bottle  soon 
become  coated  with  solid  kinate.  Kinate  of  quinia  has  so  far  given 
satisfaction,  and  as  it  possesses  the  two  great  attributes  of  solubility  and 
neutrality,  I  think  that  perhaps  this  salt  will  supply  a  want  which  has 
existed. 
M.  Yvon,  in  the  "Jour,  de  Phar.  et  de  Chim.,"  recommends  the 
use  of  lactate  of  quinia  for  hypodermic  injection,  and  in  "  L'Union 
Pharm."  of  last  May,  the  sulphovinate  of  quinia  is  stated  to  be  very 
suitable  for  the  same  purpose.  It  would  be  interesting  to  know  what 
results  have  followed  the  use  of  these  salts. — Phar,  'Jour,  and  Trans. y 
Aug.  10,  1878. 
