148  Notes  on  the  Joyote  of  Mexico.       {  AVPXXTm'' 
The  same  bird  was  made  to  swallow  a  teaspoonful  of  the  oil  ex- 
tracted with  ether.  It  was  attacked  with  cough  ;  after  half  an  hour 
vomited  some  green  matter  with  some  of  the  oil,  without  being  relieved. 
Four  hours  after  it  became  comatose  and  paralyzed  in  both  legs,  and 
half  an  hour  later  died  without  convulsions. 
On  the  9th,  half  a  teaspoonful  of  the  same  oil  was  administered  to- 
each  one  of  two  large  pigeons.  They  vomited  it,  and  rapidly  recovered. 
To  the  same  birds,  more  than  half  a  teaspoonful  of  the  same  oil  was 
given  June  10th.  One  vomited,  and  nevertheless  died  half  an  hour 
afterwards,  having  coughed  some.  The  other  neither  coughed  nor 
vomited,  but  remained  affected,  and  after  six  hours  was  comatose  with 
the  legs  paralyzed,  and  soon  after  died. 
On  the  nth,  another  pigeon  was  injected  by  the  rectum  with  a 
small  spoonful  of  the  same  oil,  and  the  anus  was  closed  with  a  band- 
age. Half  an  hour  afterwards  it  trembled  in  the  legs,  vomited  repeat- 
edly, and  when  the  stomach  was  empty,  had  continuous  nausea  ;  an 
hour  and  a  half  afterwards  had  convulsions  in  the  wings,  the  legs 
motionless,  but  not  rigid,  followed  by  a  comatose  state,  followed  by 
death  three  hours  after  injection. 
On  the  17th,  two  spoonfuls  of  the  oil  of  joyote  extracted  by  pressure 
were  injected  to  each  of  two  large  pigeons.  They  vomited,  and  died 
in  an  hour  and  a  half,  without  showing  any  other  symptom. 
The  result  of  these  experiments  is,  1st  :  That  the  oil  of  the  joyote- 
seed,  either  extracted  by  ether  or  pressure,  is  poisonous  to  pigeons. 
2d  :  That  it  produces  on  these  birds  slight  convulsions  of  the  wings, 
paralysis  of  the  legs,  comatose  state  and  death  Difficult  respiration 
is  also  observed,  and  continued  vomiting  when  the  oil  is  swallowed  or 
injected  by  the  rectum. 
On  the  10th  of  June,  the  active  principle  of  the  joyote,  dissolved  in 
a  small  quantity  of  alcohol,  was  injected  sub-cutaneously  to  two  large 
frogs.  In  a  little  while  they  became  sleepy,  apparently,  and  opened 
their  mouths  as  if  in  want  of  air  ;  they  had  but  a  few  convulsive  move- 
ments, troubled  mobility,  and  scarcely  exhibited  sensibility  even  on 
burning  their  feet.  After  an  hour  death  occurred.  The  active  prin- 
ciple of  the  joyote-seeds,  therefore,  acts  upon  frogs  as  a  poison,  paral- 
yzing the  voluntary  as  well  as  the  respiratory  muscles,  producing 
asphyxia  and  death. 
On  the  nth  of  June,  a  rabbit  was  injected  with  an  alcoholic  solu- 
