234  Formulas.  { kmd™\p£'m- 
thymol,  thus  prepared,  is  liquid,  of  a  weak  odor  of  thyme,  little  soluble 
in  water,  freely  soluble  in  alcohol,  possesses  caustic  properties,  and  has 
the  composition  C10HuO. 
Solution  of  thymic  acid  (i  per  mille).- — Dissolve  one  gram  of 
thymic  acid  in  four  grams  of  stronger  alcohol,  and  add  995  grams  of 
water.   This  solution  is  employed  in  lotions,  injections,  inhalations,  etc. 
Crystallized  aconitia. — Powdered  aconite  root  is  exhausted  by 
strong  alcohol,  containing  one  per  cent,  of  tartaric  acid  ;  the  liquid  is 
distilled  at  a  moderate  heat,  contact  with  the  air  being  avoided  ;  the 
residue  is  taken  up  with  water  to  remove  fatty  and  resinous  substances, 
and  then  agitated  with  ether  to  remove  coloring  matter.  An  alkaline 
bicarbonate  is  now  added  to  the  acid  aqueous  solution  until  efferves- 
cense  ceases,  after  which  it  is  agitated  with  ether,  the  etherial  liquid 
concentrated  and  mixed  with  some  light  petroleum  benzin,  when  the 
aconitia  will  be  obtained  in  colorless  rhombic  or  hexagonal  tables  which 
are  soluble  in  alcohol,  ether,  benzol  and  chloroform,  and  insoluble  in 
glycerin  and  the  oils  of  petroleum.  It  composition  is  represented  by 
C27HJ0NO10. 
Crystallized  nitrate  of  aconitia  is  readily  obtained  by  neutral- 
izing nitric  acid,  sp.  grav.  1*42,  with  the  alkaloid  and  concentrating  the 
solution  j  the  crystals  are  voluminous. 
Apomorphia. — One  part  of  pure  morphia  and  twenty  parts  of  pure 
hydrochloric  acid  are  introduced  into  a  strong  tubular  glass  vessel 
having  at  least  fifteen  times  the  capacity  of  the  mixture  \  the  open  end 
is  then  carefully  sealed,  the  tube  introduced  into  a  metallic  tube,  closed 
by  a  screw  cap,  and  the  whole  immersed  for  three  hours  in  an  oil 
bath,  heated  to  between  140  and  I50°C.  (near  300°F.)  After  cooling, 
the  tube  is  opened  (no  gas  being  disengaged),  the  liquid  diluted  with 
water,  and  bicarbonate  of  sodium  added  in  excess,  whereby  apomorphia 
mixed  with  morphia  is  precipitated.  The  liquid  is  decanted,  and  the 
precipitate  exhausted  by  ether  (or  chloroform  ?),  which  dissolves  only 
the  apomorphia.  The  etherial  solution  is  mixed  with  a  few  drops  of 
hydrochloric  acid  to  precipitate  crystalline  chlorhydrate  of  apomorphia,. 
the  crystals  are  rapidly  washed  with  some  cold  water,  and  recrystallized 
from  boiling  water.  To  obtain  the  new  alkaloid  from  this  hydrochlor- 
ate,  its  concentrated  aqueous  solution  is  precipitated  by  bicarbonate  of 
sodium,  the  white  precipitate  is  rapidly  washed  with  a  little  cold  water 
and  at  once  dried. 
