Am.  Jour.  Pharm.  \ 
Oct.,  1877.  J 
Laboratory  Notes. 
487 
citrate  with  quinia  added  thereto,  making  the  double  citrate  slightly 
basic.    (It  contains  1  part  quinia  [hydrate]  to  6  parts  of  the  citric  acid  ^ 
used,  equal  to  1  part  quinia  sulphate  to  about  5  parts  citric  acid.) 
It  was  found  by  Mr.  Holloway  that  a  solution  of  citrate  of  iron  and 
ammonium,  as  basic  as  the  U.  S.  preparation  of  this  name,  does  not 
perfectly  dissolve  quinia  or  quinia  sulphate,  at  least  to  make  perma- 
nently soluble  scales.  The  U.  S.  citrate  of  iron  and  ammonium 
requires  the  addition  of  citric  acid,  with  the  quinia  (approaching  the 
proportions  of  the  British  preparation),  to  make  from  it  a  good  quinia  , 
ferri  citrate.  Mr.  Holloway  prepared  two  samples  as  follows  :  Normal 
ferric  citrate  solution  (U.  S.  P.)  was  taken  in  two  portions,  each  of 
1  fluidounce,  in  each  48  grains  of  quinia  sulphate  were  dissolved,  and 
then  \\  fluidrachms  of  water  of  ammonia  (half  the  proportion  for  U.S. 
citrate  of  iron  and  ammonium  were  added  ;  then  citric  acid  was  added, 
to  portion  one  2  grains,  to  portion  two  3  grains  ;  both  portions  were 
scaled.  Portion  one  gave  the  largest  scales,  which  dissolved  with  tol- 
erable readiness,  but  on  diluting  the  solution  there  was  some  turbidity 
from  separation  of  quinia  (as  occurred  more  decidedly  in  preparations 
made  with  more  ammonia).  The  scales  of  portion  two  were  very 
easily  and  quite  permanently  soluble.  The  product  of  portion  one 
weighed  296  grains,  of  portion  two  288  grains  ;  portion  one  yielded 
14*2  per  cent,  of  quinia  (steam-bath  residue  from  chloroform  solution), 
portion  two  14*9  per  cent. 
If  the  quinia  sulphate  is  to  be  precipitated  (see  Note  VI),  I  would 
suggest  that  in  dissolving  it  for  this  purpose  citric  acid  solution  be  used 
instead  of  sulphuric  acid,  and  that  the  precipitate  be  made,  in  a  limited 
quantity  of  solution,  by  adding  a  slight  excess  of  ammonia,  and  drained 
without  washing.  The  citrate  of  iron  solution,  in  any  case,  should  be 
prepared  free  from  sulphate,  by  washing  the  iron  hydrate  to  chemical 
test. 
IX.  Examination  of  Sugars  and  Syrups. 
The  samples  examined  were  sent  by  Mr.  L.  Rossiter,  of  Lake 
Forest  (Chicago),  Illinois.  Mr.  Rossiter  is  the  writer  of  numerous 
letters,  published  in  the  "  Chicago  Tribune"  in  the  summer  and 
autumn  of  1876,  on  the  poisonous  effects  of  sugars.  He  believes  that 
a  large  proportion  of  the  sugars  of  the  market  contain  poisonous  im- 
purities, resulting  from  the  use  of  chemicals  in  their  manufacture,  his 
