120 
Euparin. 
J  Am.  Jour.  Pharm. 
t      March,  1894. 
EUPARIN. 
By  Charles  C.  Manger. 
Contribution  from  the  Chemical  Laboratory  of  the  Philadelphia  College  of  Pharmacy. 
No.  130. 
This  compound,  from  Enpatorium  purpureum,  was  described  by 
Professor  Henry  Trimble,  in  the  American  Journal  of  Pharmacy, 
1890,  p.  73. 
The  history  and  method  of  preparation  were  then  described. 
From  the  results  obtained  in  the  investigation  at  that  time,  the 
empirical  formula  (C12Hn03)  was  assigned  it,  but  it  was  not  possible 
to  classify  it  with  any  of  the  known  plant  compounds.  With  a  view 
of  adding  something  to  our  knowledge  concerning  it,  this  work 
was  undertaken  on  a  liberal  supply  of  the  crude  material  furnished 
by  Professor  Lloyd,  of  Cincinnati,  and  by  Mr.  E.  G.  Eberhardt,  of 
Indianapolis. 
The  substance  supplied  was  purified  by  digesting  an  alcoholic 
solution  of  it  with  animal  charcoal  and  subsequently  recrystallizing. 
By  these  treatments  the  euparin  was  obtained  in  acicular  or  pris- 
matic crystals  which  melted  constantly  at  n6°  C. 
That  the  purity  of  these  might  be  further  proven,  the  substance 
was  submitted  to  ultimate  analysis.  The  following  was  the  average 
of  the  results  of  the  several  combustions  which  were  made : 
Calculated  for 
Found  (C12Hn03). 
Per  Cent.  Per  Cent. 
Carbon,   70*80  70*94 
Hydrogen,   5-31  5*42 
Oxygen,   23*89  23*64 
When  carefully  heated  the  crystals  sublimed. 
Euparin  was  found  to  be  insoluble  in  water,  sparingly  soluble  in 
petroleum  ether,  readily  soluble  in  ether,  chloroform,  benzol  and 
acetone.  When  water  was  added  to  its  solution  in  the  last-named 
solvent  the  euparin  appeared  to  be  precipitated  in  direct  proportion 
to  the  degree  of  dilution,  although  the  very  dilute  solution  still 
retained  traces  of  the  substance. 
Ten  per  cent,  aqueous  solution  of  potassium  hydrate  dissolved 
the  crystals,  but  dilution  with  water  precipitated  the  substance, 
apparently  unchanged. 
Ferric  chloride  gave  a  grass  green  color  with  an  alcoholic  solution 
of  euparin. 
