582 
Rubus  Villosus. 
(  Am.  Jour.  Pharm. 
\  December,  1894. 
It  was  slowly  dissolved  by  solutions  of  the  alkali  hydrates  with 
the  production  of  a  yellow  color. 
An  aqueous  solution  of  lead  acetate  produced  no  change  in  a 
water  solution  of  the  substance,  but  an  alcoholic  solution  of  this  rea- 
gent and  also  basic  lead  acetate  gave  white  precipitates  with  the 
same  liquid. 
Sulphuric  acid  in  contact  with  the  residue  developed  a  brownish 
color,  which  changed  on  the  addition  of  one  or  two  drops  of  water, 
and  the  application  of  gentle  heat,  into  violet  and  deep  blue. 
Sulphuric  acid  and  a  drop  of  nitric  acid  caused  an  orange-red 
color,  destroyed  by  heat  as  well  as  by  the  addition  of  a  few  drops 
of  water. 
The  aqueous  solution,  from  which  this  principle  had  been 
removed  by  means  of  ether,  was  evaporated  under  reduced  pressure 
to  dryness.  The  residue  was  dissolved  in  water  containing  one  per 
cent,  of  hydrochloric  acid,  and  the  solution  so  obtained  boiled  for 
several  hours  with  the  production  of  a  reddish-brown  precipitate. 
This  was  collected,  dissolved  in  alcohol,  and  the  solution,  after  filtra- 
tion, allowed  to  evaporate  spontaneously  whereby  a  brownish  crys- 
talline mass  was  procured.  To  prepare  a  larger  quantity  of  this 
product,  the  experiment  was  repeated  with  six  kilos  of  bark  which 
were  exhausted  with  alcohol,  sp.  gr.  -820. 
The  percolate  was  concentrated  and  detannated  as  above,  then 
mixed  with  sufficient  hydrochloric  acid  to  produce  a  solution  con- 
taining one  per  cent,  of  absolute  gas.  This  solution  was  boiled  for 
several  hours,  the  precipitate  formed  was  collected,  and  the  filtrate 
after  concentration  allowed  to  evaporate  spontaneously  over  sul- 
phuric acid  whereby  a  brownish  residue  was  obtained. 
The  precipitate  produced  by  the  action  of  hydrochloric  acid  was 
treated  with  alcohol,  sp.  gr.  -848. 
The  brownish  residue  left  upon  the  spontaneous  evaporation  of 
that  solvent  when  purified  by  repeated  solution,  filtration,  and  treat- 
ment with  animal  charcoal  was  finally  acquired  as  a  yellowish- 
brown,  indistinctly  crystalline  mass. 
This  was  treated  with  ether,  which  dissolved  a  portion,  and  left 
undissolved  a  residue  that  retained  the  original  color.  The  ethereal 
solution  was  set  aside  to  evaporate.  The  following  properties  of  the 
insoluble  part  of  the  crystalline  mass  were  noted :  Insolubility  in 
ether  and  chloroform  ;  sparing  solubility  in  cold  and  hot  water  ; 
