54  Assay  Process  for  Quinine  in  Tablets.  { A™eb/uary  Pi9iF' 
The  titer  test  of  temperature  of  turbidity  of  the  mixed  fatty  acid 
is  22°  C. 
The  mixed  fatty  acid  contains  8.14  per  cent,  of  lauric  acid  as  was 
found  by  fractional  distillation  of  the  oil  in  vacuo. 
Chemical  Laboratory,  Presedency  College,  Calcutta. 
AN  ASSAY  PROCESS  FOR  QUININE  IN  TABLETS. 
By  Sidney  F.  Fieselmann,  Peoria,  111. 
A  rapid  method  for  the  quantitative  estimation  of  quinine  in 
tablets,  containing  no  other  chloroform  soluble  constituents,  that  are 
not  expelled  at  a  temperature  of  1250  C,  which  has  been  successfully 
used  by  the  author  with  accurate  results,  is  the  following : 
Count  out  a  sufficient  number  of  tablets,  so  as  to  make  the  total 
number  represent  10  grains  of  quinine  or  quinine  salts,  based  on 
the  quantity  claimed  on  the  label.  If  the  quantity  stated  per  tablet 
cannot  be  made  to  come  out  in  a  whole  number  of  tablets,  take  the 
number  of  tablets,  which  contain  about  10  grains  and  make  the 
required  correction.  Weigh  the  tablets  counted  out  accurately  on  an 
analytical  balance.  Multiply  this  weight  by  two  and  call  it  X  grams. 
Then  powder  a  sufficient  amount  of  tablets  and  force  all  through  a 
number  sixty  sieve.  In  case  of  coated  tablets  be  careful  not  to 
loose  any  particle  of  the  hard  coating  or  parts  of  tablets  during  the 
process  of  powdering  and  sifting.  Then  mix  thoroughly  after  this 
operation,  so  as  to  insure  a  uniform  representative  mixture. 
Weigh  up  X  grams  of  this  powder  in  a  100  c.c.  Erlenmeyer 
flask,  add  50  c.c.  of  chloroform,  accurately  measured,  stopper 
and  shake  well.  Now  add  5  c.c.  of  ammonia  water  U.  S.  P., 
stopper  well  and  shake  thoroughly  for  20  minutes.  Let  stand  for 
about  12  hours  in  a  cool  place,  with  occasional  shaking,  and  decant 
the  chloroform  into  a  separatory  funnel,  stopper  well  and  allow  to 
stand  until  separation  takes  place.  Take  a  5  cm.  plain  folded  filter 
paper,  on  a  small  60 0  glass  funnel,  moisten  with  a  little  chloroform, 
taking  care  not  to  have  any  chloroform  drop  into  the  measuring 
cylinder  or  any  remaining  in  the  tube  of  the  funnel.  Then  withdraw 
enough  of  the  chloroformic  solution  in  the  separating  funnel  and 
filter  the  same  through  the  moistened  filter  paper  into  a  50  c.c. 
measuring  cylinder  until  25  c.c.  are  obtained. 
