134 
Progress  in  Pharmacy. 
f  Am.  Jour.  Pharm. 
\     March,  1914. 
others  have  found  that  it  is  fully  as  toxic  as  cocaine  and  the  last  sup- 
plement to  the  German  Pharmacopoeia  gives  the  maximum  dose  the 
same  for  both  alypin  and  cocaine. — Therap.  Monatsh.,  Berlin,  1913, 
v.  27,  p.  787. 
Arheol  is  a  proprietory  name  for  santalol,  C15H26OH,  a  sequi- 
terpenic  alcohol,  the  chief  constituent  of  sandalwood.  Arheol  is 
a  colorless,  oily  liquid;  specific  gravity,  0.979  at  150  C.  It  is  in- 
soluble in  water  but  soluble  in  alcohol.  It  boils  under  1 1  mm.  pres- 
sure at  1690,  and  under  ordinary  pressure  at  about  5000  C. — /.  Am. 
M.  Assoc.,  1913,  v.  61,  p.  1900. 
Atophan,  Secondary  Effects  of. — Phillips,  John, calls  attention 
to  the  occurrence  of  various  skin  rashes  caused  by  the  administra- 
tion of  atophan  and  reports  5  cases.  These  rashes  resemble  those 
following  the  administration  of  antipyrine  and  indicate  that  atophan 
should  not  be  given  in  the  treatment  of  urticaria  as  has  been  advised. 
— /.  Am.  M.  Assoc.,  1913,  v.  61,  p.  1040. 
Behring's  Diphtheria  Vaccine. — Kissling,  K.,  reports  on  the 
application  of  Behring's  new  vaccine  to  immunize  children  who  had 
been  exposed  to  diphtheria  in  different  wards  of  the  Hamburg 
general  hospital.  Of  the  310  children  treated,  111  were  given  a  sec- 
ond injection  and  none  of  this  group  has  contracted  diphtheria,  and 
only  8  among  the  remaining  199.  In  these  cases  the  patients  were 
convalescing  from  scarlet  fever  and  the  diphtheria  was  exceptionally 
mild,  or  the  vaccine  did  not  have  time  to  act  before  the  diphtheria 
developed ;  several  days  are  required  for  the  vaccine  to  complete 
the  immunization.  Adults  respond  with  more  of  a  reaction  to  the 
vaccine  than  children.  Pre-existing  disease  of  any  kind  does  not 
seem  to  be  a  contra-indication.  (Deutsch.  med.  Wchnschr.,  1913, 
v.  39,  No.  51.) — /.  Am.  M.  Assoc.,  1914,  v.  62,  p.  418. 
Cereus  Grandiflorus. — Grober,  A.  Many  contradictory  state- 
ments have  been  published  as  to  the  activity  of  Cactus  grandiflorus 
and  its  value  as  a  heart  remedy.  The  pharmacological  experiments 
of  the  author  show  that  the  drug  exerts  some  action  on  the  frog's 
heart  similar  to  digitalis.  This  may  be  attributed  to  the  glucoside 
present  as  well  as  to  the  alkaloid.  The  amount  of  active  principles 
present  in  the  drug  is,  however,  so  small,  that  it  cannot  be  consid- 
ered in  any  way  as  a  substitute  for  digitalis  in  human  therapeutics. — 
Therap.  Monatsh.,  1913,  v.  27,  pp.  580-581. 
Chromium  Sulphate. — Kolipinski,  S.,  is  quoted  as  saying: 
"  The  diseases  in  which  chromium  has  been  used  with  success  are : 
