AmAp?nr'i9ih4rm" }  Solubility  of  Phenol  in  Hydrocarbons.  149 
3.  Adrenalin  Chloride  Solution  can  be  exposed  to  the  air  and 
sterilized  at  least  twice  under  a  variety  of  conditions  without  loss 
of  activity. 
4.  Adrenalin  Chloride  Solution  is  more  stable  than  the  Solution 
of  a  synthetic  compound  when  both  are  subjected  to  the  same  sterili- 
zation treatment.  The  results  obtained  disprove  the  statement  that 
the  stability  of  the  synthetic  exceeds  that  of  the  natural  product. 
REFERENCES. 
1  Aldrich :   Jour.  Amer.  Chem.  Soc,  September,  1905. 
2  Stoll :  Lancet-Clinic,  June  21,  1913. 
3  Houghton:  Jour.  Amer.  Med.  Assoc.,  January  18,  1902. 
From  the  Research  Laboratory  of  Parke,  Davis  &  Co.,  Detroit, 
Michigan. 
NOTE  ON  THE  SOLUBILITY  OF  PHENOL  IN 
HYDROCARBONS. 
By  J.  D.  PlLCHER. 
Pharmacological  Laboratory,  School  of  Medicine,  Western  Reserve 
University,  Cleveland. 
The  Pharmacopoeia  states  that  Phenol  is  very  soluble  in  fixed 
oils.  It  is  less  soluble  in  the  mineral  oils ;  as  determined  in  this 
laboratory  one  gram  of  Phenol  dissolves  in  8-9  c.c.  of  Petroleum, 
20-21  c.c.  Petroleum  benzine,  45-50  c.c.  of  Petrolatum  liquidum. 
It  is  about  twice  as  soluble  in  solid  Petrolatum  (1  in  23-24)  as  in 
the  liquid  petrolatum.  This  difference  in  solubility  of  Phenol  in 
the  vegetable  and  animal  oils  and  in  the  mineral  oils  is  worthy  of 
note  for  two  reasons :  In  removing  Phenol  from  the  skin  after  acci- 
dental application  the  mineral  oils  would  be  less  efficacious  than  the 
fixed  oils,  glycerin  and  alcohol  and  of  little  more  value  than  water. 
However,  when  the  local  "action  is  desired,  ointments  and  liquid 
preparations  of  Phenol  in  the  mineral  oils  would  be  more  active  than 
preparations  containing  the  same  percentage  of  Phenol  in  the  animal 
or  vegetable  oils,  inasmuch  as  the  mineral  oils  would  part  with  the 
Phenol  more  readily  than  the  other  oils. 
Methods. — Weighed  amounts  of  crystallized  Phenol  were  added 
to  the  liquid  hydrocarbons  and  allowed  to  stand,  with  frequent 
