Am.  Jour.  Pharm. 
June,  1914. 
Progress  in  Pharmacy. 
279 
being  offered  as  a  "  valuable  therapeutic  agent." — /.  Am.  M.  Assoc., 
1914,  vol  62,  pp.  793,  794.    See  also  pp.  1033-1035. 
Argyrism. — Crispin,  Antonio  M.,  reports  a  case  of  argyrism  fol- 
lowing the  use  of  collargol.  The  administration  of  potassium  iodide 
had  not  the  slightest  effect  on  the  resulting  color  of  the  skin.  The 
subsequent  administration  of  hexamethylenamine  caused  the  color  to 
fade  and  become  several  shades  lighter. — /.  Am.  M.  Assoc.]  1914, 
vol.  62,  p.  1394. 
As  pido  spermine.  (Cow,  Douglas.) — Experimental  observations 
on  the  action  of  the  alkaloids  of  quebracho.  Quebrachine  is  by  far 
the  most  toxic  of  the  four  alkaloids  investigated.  In  small  doses 
quebrachine  exerts  a  stimulating  action  on  the  central  nervous  sys- 
tem, as  also  do  the  other  alkaloids.  The  only  obvious  objective  effect 
of  this  is  seen  in  the  respiration,  which  becomes  both  quicker  and 
deeper. — /.  Pharmacol,  and  Exper.  Therap.,  1913-1914,  vol.  5,  pp. 
341-356.  ^ 
Aspirin.  (Reed,  Edward  N.) — Report  of  a  case  of  idiosyncrasy 
to  aspirin  (acetylsalicylic  acid)  in  which  vomiting,  cyanosis,  and 
oedema  followed  the  ingestion  of  5  grains  of  the  drug.  No  treatment 
was  instituted,  and  in  about  six  hours  the  patient  was  comfortable. — 
/.  Am.  M.  Assoc.,  1914,  vol.  62,  p.  773.    See  also  p.  797. 
Creolin  consists  of  the  glycerides  of  fatty  acids  along  with  chol- 
esterins,  lecithin,  and  ethereal  oil,  all  of  which  are  found  in  yeast. 
It  is  prepared  by  extracting  fresh  purified  beer  yeast  with  alcohol 
and  separating  the  dissolved  fat  from  the  alcoholic  extract  by  suit- 
able means.  Creolin  is  said  to  be  useful  in  furunculosis,  acne,  sycosis, 
and  similar  affections  of  the  skin.  It  is  also  said  to  be  useful  in 
habitual  constipation,  leucorrhoea,  erosions  of  the  vagina  and  cervix, 
and  similar  diseases. — -/.  Am.  M.  Assoc.,  1914,  vol.  62,  p.  931. 
Cocaine.  (Editorial.) — The  demand  for  cocaine  for  legitimate 
medicinal  uses  appears  to  have  diminished  considerably  in  recent 
years.  Some  of  the  large  firms,  which  formerly  handled  many  thou- 
sands of  ounces  of  cocaine  in  the  course  of  the  year,  now  do  not  sell 
so  many  hundreds,  while  other  firms  which  also  dealt  in  the  article 
in  not  inconsiderable  quantities  now  sell  practically  none. — Pharm. 
J.,  1914,  vol.  92,  p.  466. 
Collargol.  (Eisendrath,  Daniel  E.) — A  preliminary  note  on  the 
effect  of  injecting  collargol  into  the  renal  pelvis.  The  report  states 
that  death  resulted  in  animals  from  extensive  and  widely-distributed 
collargol  embolism,  and  the  author  believes  that  these  experiments 
