Am.  Jour.  Pharm. 
June,  1914. 
Progress  in  Pharmacy. 
283 
lein-agar  is  prepared  by  impregnating  1000  Gm.  of  agar-agar  with  a 
solution  obtained  by  dissolving  30  Gm.  of  phenolphthalein  in  a  mix- 
ture of  2000  Cc.  of  water  and  700  Cc.  of  alcohol  and  drying  the 
impregnated  agar-agar  slowly. — /.  Am.  M.  Assoc.,  1914,  vol.  62, 
p.  1 168. 
Quinine  Poisoning.  (Underhill,  Elizabeth  C.) — Report  of  a  case 
of  quinine  poisoning  in  a  woman,  age  20,  who  took  at  one  dose  100 
2-grain  quinine  pills.  The  toxic  symptoms  were  accompanied  by 
impairment  of  vision,  which  improved  gradually. — /.  Am.  M.  Assoc., 
1914,  vol.  62,  pp.  1396,  1397.    See  also  p.  920. 
Quinine-urea  Hydrochloride.  (Abstract.) — There  is  a  certain 
element  of  danger  attending  the  use  of  quinine-urea  hydrochloride  as 
a  local  anaesthetic.  It  has  been  pointed  out  that  sloughing  may  follow 
its  use  when  a  solution  stronger  than  3  per  cent,  is  used.  An  exten- 
sive abscess  has  followed  the  use  of  a  1  per  cent,  solution  for  the 
removal  of  internal  hemorrhoids,  and  two  cases  of  sloughing  follow- 
ing the  use  of  a  2  per  cent,  solution  in  similar  operations  are  re- 
corded. The  general  opinion  is  that  solutions  of  this  substance  should 
not  be  stronger  than  1  per  cent. ;  some  observers  recommend  even 
weaker  solutions,  and  with  proper  attention  to  technic  bad  effects 
may  be  greatly  reduced. — Pharm.  J.,  1914,  vol.  92,  p.  368. 
Riopan. — A  concentrated  preparation  of  ipecacuanha  sent  out 
as  a  brownish  powder,  soluble  in  water.  It  is  standardized  to  con- 
tain 50  per  cent,  of  ipecacuanha  alkaloids  in  the  form  of  their  hydro- 
chlorides; the  other  more  or  less  inert  substances  are  also  present. 
One  part  of  riopan  is  equivalent  to  20  parts  of  ipecacuanha  root. — 
Chem.  and  Drug.,  1914,  vol.  84,  p.  443. 
Salvarsan. — No  one  can  dispute  the  statement  that  many  of  the 
deaths  from  salvarsan  have  been  caused  by  its  ill-considered  use, 
either  in  the  face  of  contra-indications  or  in  too  large  or  too  fre- 
quent dosage,  but  to  argue  from  this  that  the  fatalities  are  therefore 
not  due  to  salvarsan  and  that  salvarsan  is  not  toxic  is  far  from 
logical.  The  unwise  use  of  salvarsan  may  be  expected  as  a  result  of 
such  arguments,  and  the  stubborn  denial  of  the  toxicity  of  the  drug 
has  encouraged  its  careless  administration. — /.  Am.  M.  Assoc.,  1914, 
vol.  62,  p.  1 176. 
Neosalvarsan.  (Anon.) — Seven  deaths  have  occurred  in  the  Los 
Angeles  Hospital  within  two  days  following  intraspinal  injections 
of  a  solution  of  neosalvarsan  in  autogenous  serum,  and  another 
patient  is  reported  as  being  likely  to  die. — /.  Am.  M.  Assoc.,  1914, 
vol.  62,  pp.  861,  862.   See  also  pp.  957,  958. 
