Am' jSr'i9i4arm' }     Chemistry  of  Pressor  Compounds.  303 
says,  "  Es  gibt  Peptone  ohne  Peptonwirkung  unci  Peptonwirkung 
ohne  Peptone."  A  number  of  so-called  peptons  produce  eosinophilia 
in  varying  degrees.  In  some  cases  of  acromegaly,  a  disease  asso- 
ciated with  pituitary  disturbances,  eosinophilia  has  been  reported.43 
Some  pepton  preparations  induce  symptoms  similar  to  those 
which  occur  during  the  anaphylactic  reaction.  Biedl  *3a  claims  that 
Urechia's  results  with  the  intraperitoneal  injections  of  pituitary 
extracts  must  be  interpreted  as  an  anaphylactic  reaction,  and  Pan- 
kow  44  found  that,  after  the  intravenous  injection  of  1—5  c.c.  of 
Pituitrin,  rabbits  became  more  sensitive  to  a  second  injection  made 
in  from  1  to  5  days  after  the  first.  According  to  Fiihner,  the  respi- 
ratory stoppage  from  Pituitrin  resembles  that  from  anaphylaxis.45 
Extracts  of  the  posterior  lobe  are  said  to  accelerate  coagulation  of 
the  blood,  while  those  from  the  anterior  lobe  retard  it.46  Witte's 
pepton,  especially  the  portion  soluble  in  absolute  alcohol,  retards 
coagulation.47 
The  pituitary  gland  contains  various  enzymes,  which  might  form 
pepton-like  bodies.48 
Paal,49  by  treating  albumen  with  hydrochloric  acid,  has  obtained 
products  which  he  calls  salts  of  pepton.  These,  unlike  pepton,  are 
soluble  in  alcohol.  Schrotter  50  claims  to  have  obtained  similar  com- 
pounds with  albumoses.  Peptons  consist  mainly  of  mono-amino 
acids,  and,  according  to  De  Waele,  the  pepton  action  is  primarily 
43Falta,  W.,  "Die  Erkrankungen  der  Blutdrusen,"  1913,  p.  212. 
43a  Biedl,  "  Innere  Sekretion,"  vol.  2,  p.  133  (1913)  ;  Urechia,  C.  J.,  "  Action 
de  l'extrait  hypophysaire  en  injections  intraperitoneales,"  Comp.  rend.  Soc. 
de  Biol,  vol.  65,  p.  278  (1908). 
44  Biedl,  /.  c.,  vol.  2,  p.  136. 
45  Fiihner,  /.  c.,  p.  406. 
40  £mile-Weil,  P.,  and  Boye,  G.,  "  Action  differentes  des  lobes  hypophy- 
saires  sur  la  coagulation  du  sang,"  Comp.  rend.  Soc.  de  Biol.,  vol.  67,  p. 
428  (1909). 
47  Zunz,  E.,  "Apropos  de  Taction  anticoagulante  des  injections  intra- 
veineuses  de  peptone  de  Witte,"  Comp.  rend.  Soc.  de  Biol,  vol.  73,  p.  50 
(1912). 
48  Buetow,  "  Zur  Kenntniss  der  Hypophysenzyme,"  Biochem.  Zeits.,  vol.  54, 
p.  40  (1913). 
49  Paal,  C,  "  Ueber  die  Peptonzalze  des  Eieralbumine,"  Ber.  d.  dcutsch. 
chem.  Gesells.,  vol.  27,  p.  1845. 
60  Schrotter,  Monats.  f.  Chemis.,  vol.  14,  p.  612  (1893). 
