304  Chemistry  of  Pressor  Compounds.  {Am'ju?vr'i^i4arm' 
an  amino  action.  From  Witte's  pepton  Pick  51  claims  to  have  sepa- 
rated two  peptons  and  four  albumoses.  However,  as  Haslam  points 
out,  the  methods  do  not  give  sharp  separations.52  Pick  precipitated 
the  primary  albumoses  by  means  of  ammonium  sulphate,  and  sepa- 
rated them  by  alcohol ;  the  hetero-albumoses  53  being  precipitated  by 
weak  ethyl  alcohol,  while  the  proto-albumoses  remained  in  solution 
with  rather  strong  alcohol.  The  hetero-albumoses  would  precipi- 
tate on  dialysis,  and  long  heating  converted  them  into  an  insoluble 
compound  (dysalbumid) .  Witte's  pepton  contained  very  little 
of  the  proto-albumoses.  After  ammonium  sulphate  precipitation 
the  filtrate  yielded  a  product  which  was  called  albumose  C.  On 
treating  the  hetero-albumoses  54  with  hydrochloric  acid  no  tyrosin 
was  obtained,  but  large  amounts  of  leucin  were  found,  while  oxida- 
tion with  potassium  permanganate  yielded  a  compound  believed  to 
be  phenyl-amino-propionic  acid.  The  proto-albumoses  yielded 
tyrosin  and  gave  a  marked  skatol  odor  on  decomposition.  Pick's 
hetero-albumose  contained  no  indol  nucleus,  but  yielded  large 
amounts  of  di-amino  compounds. 
In  one  experiment  Pick  noted  that  both  the  proto-albumoses  and 
hetero-albumoses  obtained  from  Witte's  pepton  caused  a  rise  in 
blood-pressure,  but  as  these  albumoses  had  been  prepared  by  the 
ammonium  sulphate  method  the  rise  may  have  been  due  to  some  of 
the  precipitant,  However,  another  dog  merely  responded  by  a  fall 
in  blood-pressure  when  hetero-albumose  was  injected,  and  in  Popiel- 
ski's  experiments  proto-albumose,  prepared  by  Pick's  method,  pro- 
duced a  rise  in  blood-pressure  in  one  case,  but  a  fall  in  the  second,55 
r'1  Pick,  E.  P.,  "  Zur  Kenntniss  der  peptischen  Spaltungsprodukte  des  Fi- 
brins," Zcits.  f.  physiol.  Chem.,  vol.  28,  p.  219  (1899)  ;  Bcitrag  s.  Chem. 
Physiol.,  vol.  2,  p.  481  (1902).  See  also  Zunz,  E.,  "Die  fractionirte  Abscheid- 
ung  der  peptischen  Verdauungsprodukte  mittelst  Zinksulfat,"  Zeits.  f. 
physiol.  Chem,,  vol.  27,  p.  219  (1899). 
52  Haslam,  H.  C,  "  Separation  of  Proteins,"  Jour.  Physiol.,  vol.  36,  p.  154 
(1907-08). 
53  Kiihne  and  Chittenden. 
54  Schulze,  E.,  "  Untersuchungen  ueber  die  Amidosauren  welche  bei  der 
Zersetzung  der  Eiweissstoffe  durch  Salsaure  und  durch  Barytwasser  ent- 
stehen,"  Zcits.  f.  physiol.  Chem.,  vol.  9,  p.  72. 
55  Popielski,  L.,  "  Ueber  die  Wirkungsweise  des  Chlorbaryium,  Adrenalin 
und  Pepton  Witte  auf  den  peripherischen  vasomotorischen  Apparat,"  Archiv. 
f.  cxper.  Path.,  Stipplementband  1908,  p.  44  1. 
