564 
Progress  in  Pharmacy. 
{Am.  Jour.  Pharm. 
December,  1914. 
•  The  Prognosis  in  Morphine  Addiction.  (Konig,  H.) — The  prog- 
nosis naturally  varies  according  as  the  addiction  was  acquired  in 
connection  with  <a  chronic  painful  affection,  such  as  tabes,  neuralgia, 
or  peritoneal  adhesions,  or  with  single  periods  of  pain,  such  as  gall- 
stone colic,  or  in  connection  with  periods  of  melancholia  or  insomnia. 
Experience  with  28  cases  is  reviewed,  demonstrating  a  successful 
outcome  in  over  50  per  cent,  of  the  14  in  the  gall-stone  group.  The 
treatment  required  from  three  to  ten  months  in  these  cases. — Berl. 
klin.  W chnschr.,  vol.  51,  June  1,  No.  22;  /.  Am.  M.  Assoc.,  1914, 
vol.  63,  p.  204. 
Commercial  Papain  and  Its  Assay.  (Adams,  H.  M.) — Commercial 
papain  is  sometimes  adulterated  with  starch  or  pepsin.  The 
presence  of  starch  is  shown  by  the  addition  of  iodine  solution, 
and  the  pepsin  by  comparative  observations  on  the  digestion  of 
meat  in  a  weak  acid  and  in  a  neutral  or  alkaline  solution.  To  de- 
termine the  proteolytic  power  of  papain,  neutral  solutions  give  the 
most  satisfactory  results  with  either  meat  or  the  whites  of  eggs. — 
/.  Ind.  and  Eng.  Chem.,  19 14,  vol.  6,  pp.  669,  670. 
Acitrin. — Phenolcinchoninicacidethylester,  a  yellowish,  odorless, 
and  tasteless  powder,  melting  at  590,  only  slightly  soluble  in  organic 
solvents.  On  boiling  with  acids  or  alkalies  the  ester  is  saponified. — 
Sudd.  Apoth.-Ztg.,  1914,  vol.  54,  p.  137. 
Agar-agar  Biscuits.  (Anon.) — To  make  agar-agar  biscuits  it  is 
only  necessary  to  add  the  fine  agar-agar  to  the  flour  used  in  making 
the  biscuits.  The  amount  should  be,  if  possible,  sufficient  so  that  a 
dose  (5  grammes)  may  be  included  in  each  biscuit. — /.  Am.  M. 
Assoc.,  1914,  vol.  63,  p.  1224. 
Algocratine. — Mannich  and  Leemhuis  report  an  examination  of 
a  powder  offered  as  an  infallible  remedy  for  migraine,  neuralgia, 
grippe,  influenza,  and  other  diseases.  The  preparation  was  found  to 
consist  essentially  of  a  mixture  of  phenacetin,  50  Gm.,  caffeine,  10 
Gm.,  and  pyramidon,  40  Gm.  The  claims  made  for  the  composition 
of  the  preparation  were  found  to  be  quite  untrue. — Apoth.-Ztg.,  1914, 
vol.  29,  p.  553. 
Amphotropin. — A  combination  of  camphoric  acid  and  hexa- 
methylentetramine,  C8H14  (COOH)2  [  (CH|2)6N4]2.  A  white  crys- 
talline powder  having  an  acid  reaction,  soluble  in  10  parts  of  water 
at  room  temperature,  more  readily  soluble  in  hot  water  and  in 
alcohol. — Sudd.  Apoth.-Ztg.,  1914,  vol.  54,  p.  137. 
