AFeb^ua^f.P^9w.m•}     Recent  Literature  Relating  to  Pharmacy.  83 
(7)  In  general,  one  constituent  remaining  the  same,  the  mixtures 
with  substances  of  similar  chemical  constitution  yield  similar  boil- 
ing point  curves.  One  well-marked  exception  appears :  carbon 
tetrachloride  and  chloroform  in  acetone.  L.  F.  Kebler. 
PERMANENCE  OF  IPECAC  PREPARATIONS. 
Mr.  R.  Glode  Guyer  (1899,  Pharm.  your,,  622)  assayed  a  sample 
of  liquid  extract  of  Rio  ipecac,  and  found  it  to  contain  only  1*528 
per  cent,  of  alkaloids,  whereas  two  months  previously  the  same 
preparations  contained  2-08  per  cent.  A  liquid  extract  prepared 
from  Carthagena  root  and  standardized  to  assay  2-1  per  cent,  (age 
not  given)  was  also  assayed,  and  found  to  contain  1-525  per  cent. 
These  figures  show  that  the  liquid  extracts  of  both  the  Rio  and 
Carthagena  roots  depreciate  exactly  parallel. 
Three  samples  of  wine  of  ipecac  collected  from  retailers  assayed 
0-0788,  0-0384,  0-0348  per  cent.  A  similar  number  from  whole- 
salers contained  00882,  0-1022,  0-077  per  cent,  of  total  alkaloids. 
Standard,  o-i  per  cent. 
The  questions  suggested  by  this  investigation  are  :  Does  the 
alkaloidal  value  depreciate  by  age,  or  do  the  alkaloids  deposit  on 
standing,  and  are  then  removed  by  subsequent  filtration  ? 
Note. — In  1897  Mr.  C.  H.JLaWall,  this  Journal,  69,  619,  re- 
ported on  a  thirty-three-year- old  fluid  extract,  which  contained  276 
per  cent,  of  total  alkaloids. 
In  assaying,  the  precipitate  was  carefully  excluded,  so  that  the 
above  per  cent,  represents  only  the  alkaloids  in  solution.  Recently 
the  abstractor  received  several  samples  of  fluid  extract  of  ipecac, 
made  by  Dr.  Squibb,  with  the  information  that  they  were  very  old, 
and  probably  worthless.  On  the  average  these  samples,  after  filter- 
ing, contained  1-72  per  cent,  of  total  alkaloids.  L.  F.K. 
NEW  REMEDIES  OF   1 899.1 
Acetanilit-sulphonate  of  Sodium. — Soluble  antipyretic. 
Acetophenone-ortho-oxyquinoline. — C9H6NO.CB2.CO.C6H5.  Hypno- 
tic and  antineuralgic. 
Acet-ortho-amiio-quinoline  — C()H6N(NHCH3CO).  Antipyretic. 
Acet-orthotoluid.— C6H4(CH3)NHCOCH3.  Orthotolyl-acetamide. 
Antipyretic.    Dose  :  o  1-0-3  gramme  (1  l/2-S  grains). 
1  Merck's  Report,  1900,  p.  19. 
