180        Recent  Literature  Relating  to  Pharmacy.     { Aralpri^i9(Sarm' 
digitoxin  is  C34H54On,  basing  same  on  the  formulae  of  its  products 
of  hydrolysis;  the  reaction  being 
C34H54011  +  H20  =  C22H3204  +  2C6H1204. 
Digitoxin.  Digitoxigenin.  Digitoxose. 
The  formula  ascribed  to  digitoxose  he  bases  on  its  oxime  C6H12- 
O3NOH  and  its  derived  acid  C6H1304COOH,  the  calcium  salt  and 
lactone  of  which  were  isolated  and  analyzed. 
The  formula  of  digitoxigenin  given  above  is  proven  by  molecular 
weight  estimation,  by  the  combustion  of  an  anhydro-digitoxigenin, 
C22H30O3,  made  by  treating  the  substance  with  strong  hydrochloric 
acid,  and  by  a  hydrated  product  obtained  by  treating  digitoxigenin 
with  sodium  hydrate.  This  body — C22H3305Na.H20 — is  the  so- 
dium salt  of  an  acid  called  by  the  writer  dixgeninic  acid. 
A  further  proof  of  the  above  formula  of  digitoxin  is  the  product 
obtained  by  heating  the  substance  with  sodium  hydrate  in  a  pres- 
sure flask.  This  product,  on  being  treated  with  calcium  chloride, 
yielded  a  calcium  compound — (C34H55012)2Ca.3H20 — the  acid  of 
which,  C34H56012,  he  calls  digitoxinic  acid. 
Oxidation  of  anhydro-digitoxigenin,  with  chromic  acid,  yielded  a 
product,  C19H2403  or  C20H26O3,  which  is  termed  toxigenone.  Kiliani 
then  discusses  the  composition  of  "  digitalinum  verum."  This,  he 
thinks,  is  C35H56014,  basing  his  opinion  on  its  dissociation  products, 
he  thinking  the  reaction  to  be : 
C35H56014  =  C^H^Og  -f  C6H1206  -j-  C7H14Os. 
Digitalin.         Digitaligeniti.      Dextrose.  Digitalose. 
The  above  formula  of  digitaligenin  he  bases  on  molecular 
weight  estimations  and  on  combustion  figures.  However,  the_data 
obtained  from  both  these  sources  agree  equally  well  with  the 
formula  Q3H3203;  hence  it  is  possible  that  the  formula  of  digitalin 
may  be  C36H58014. 
Oxidation  of  digitaligenin  with  chromic  acid  yielded  a  product 
identical  with  toxigenone,  mentioned  above ;  thus  showing  genetic 
relationship  between  digitoxigenin  and  digitaligenin. 
The  digitalose  formula  of  the  above  reaction  is  based  on  a 
lactone,  C7H1205,  obtained  on  treating  the  sugar  with  bromine. 
As  another  product  of  the  bromine  reaction  was  d-gluconic  acid, 
the  writer  assumes  that  dextrose  was  a  second  product  of  the 
hydrolysis  of  digitalin.    The  lactone,  C7H12Os,  on  cooking  with 
