Am.  Jour.  Pharm.  1 
May,  1900.  J 
Syrupus  Ferri  Icdidi. 
217 
Diluted  hypophosphorous  acid 
Sugar   
Spirit  of  lemon  
10  grammes. 
700  " 
5  c.c. 
Water,  a  sufficient  quantity  to  make  1,000  c.c. 
Triturate  the  hypophosphites  with  350  c.c.  of  water  and  allow 
the  undissolved  portion  to  settle. 
Pour  off  the  clear  solution,  and  to  the  residue  add  the  diluted 
hypophosphorous  acid  and  triturate  until  solution  is  effected. 
Mix  the  liquids,  add  the  spirit  of  lemon  and  filter.  In  the  filtrate 
dissolve  the  sugar  by  agitation  without  heat,  and  add  enough  water 
through  the  filter  to  make  the  product  measure  1,000  c.c. 
Strain  if  necessary.  The  alternative  process  of  percolation,  as 
directed  by  the  present  Pharmacopoeia,  should  be  included  in  the 
official  formula. 
The  experiments  conducted  were  with  the  view  of  preparing  a 
syrup  of  greater  permanence.  It  is  well  known  that  the  present 
official  formula  yields  a  less  satisfactory  syrup  than  the  one  of  the 
1880  Pharmacopoeia.  This  is  undoubtedly  due  to  a  deficiency  in 
the  amount  of  sugar,  and  several  writers  have  pointed  to  the 
necessity  of  an  increase. 
Recently  the  importance  of  adding  sugar  to  the  solution  of 
ferrous  iodide,  before  mixing  with  the  syrup  or  solution  of  the 
sugar,  has  been  recognized.  In  preparing  the  syrup  by  the  pro- 
cess of  the  1880  Pharmacopoeia,  the  necessity  of  a  sugar  addition 
becomes  apparent.  This  formula  omits  directions  to  heat  the  iron 
solution  to  boiling  and  the  washings  are  also  directed  to  be  made 
with  cold  distilled  water.  The  washings  are  frequently  cloudy  and 
the  finished  syrup  will  lack  transparency. 
The  presence  of  sugar  in  the  iron  solution  prevents  this  cloudi- 
ness and  the  present  Pharmacopoeia  very  properly  directs  the  wash- 
ing to  be  done  with  a  hot  mixture  of  syrup  and  water. 
This  somewhat  tedious  method  may  be  improved  by  diluting  the 
solution  of  ferrous  iodide,  after  reaction  has  ceased,  with  water  to 
its  full  limit,  heating  it  to  boiling,  adding  a  small  amount  of  sugar 
SYRUPUS  FERRI  IODIDI. 
By  F.  W.  Haussmann. 
