Am.  Jour.  Pharm.  \ 
December,  1900.  J 
Warburg  s  Tincture. 
573 
point."  "  We  understand  that  it  is  the  practice  of  some  pharmacists 
to  clarify  the  tincture,"  etc. 
It  further  states  that  "  it  would  seem  best  to  follow  the  semi- 
official formula  and  dispense  the  tincture  as  a  shake  mixture  until  the 
subject  receives  fuller  investigation." 
According  to  the  writer's  experience  digestion  with  diluted  alco- 
hol, as  directed  by  the  N.F.,  gives  a  preparation  that  will  not  remain 
clear  after  filtering.  Digestion  with  proof  spirit  is  also  unsatisfac- 
tory. Maceration  followed  by  percolation  with  the  diluted  alcohol, 
or  with  6  volumes  of  alcohol  and  4  volumes  of  water,  gives  some- 
what better  results,  but  such  a  tincture  will  not  remain  clear. 
Maceration  (not  percolation)  with  6  volumes  of  alcohol  and 
4  volumes  of  water  at  a  temperature  not  exceeding  150  to  200  C. 
gives  excellent  results.  A  tincture  thus  prepared  remains  bright  and 
clear,  excepting  for  a  slight  amount  of  precipitate  which  settles  to 
the  bottom. 
The  turbidity  of  the  tincture  prepared  by  digestion  on  a  water- 
bath  appears  to  be  at  least  partly  due  to  the  solution  of  oily  and 
resinous  matter  at  the  elevated  temperature,  which  is  imperfectly 
thrown  out  of  solution  on  cooling. 
Warburg's  tincture  is  not  a  concentrated  preparation  (containing 
only  about  3  per  cent,  of  extractive  matter,  not  including  the  quin- 
ine sulfate)  and  for  this  reason  it  can  be  prepared  of  proper  strength 
by  maceration.  A  tincture  prepared  by  this  method  at  a  compar- 
atively low  temperature  is  less  contaminated  with  fatty  matter,  etc. 
The  following  working  formula  has  been  used  for  several  years 
with  results  that  were  entirely  satisfactory  : 
Grammes. 
Socotrine  aloes  263 
Angelica  seed  (freshly  ground  or  crushed)  85 
Rhubarb  (ground)    85 
Elecampane  (ground)  42*5 
Crocus  (entire)  ,  42*5 
Fennel  (freshly  ground  or  crushed)  42*5 
Prepared  chalk  
Gentian  (ground)    
Zedoary  (ground)   . 
Cubebs  (freshly  ground  or  crushed)  
Myrrh  (entire  freshly  crushed)   
Camphor  
Agaric  (powdered),  of  each   21*25 
